Effects of Exercise Training on Mechanoreflex and Metaboreflex Control in Heart Failure Patients

Heart Failure Clinical Trial

Official title:

Effects of Exercise Training on Mechanoreflex and Metaboreflex Control of Muscle Sympathetic Nerve Activity in Heart Failure Patients

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT01884142
• Other study ID #: Ergoreflex
• Status: Completed
• Phase: N/A
• Start date: March 2008
• Est. completion date: January 2014

Study information

• Verified date: April 2021
• Source: University of Sao Paulo General Hospital
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

The investigators hypothesize that exercise training would improve the mechanoreflex and metaboreflex control in heart failure patients.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 34
• Est. completion date: January 2014
• Est. primary completion date: December 2012
• Accepts healthy volunteers: No
• Gender: All
• Age group: 30 Years to 65 Years

Eligibility

Inclusion Criteria:

• Patients with systolic heart failure;

• New York Heart Association (NYHA) class II-III;

• Left ventricular ejection fraction less than 40%;

• Peak Oxygen Consumption less than 20 ml/Kg/min;

• Stable Clinical Status.

Exclusion Criteria:

• Chronic Obstructive Pulmonary Disease;

• Neuromuscular Diseases;

• Orthopedic Diseases;

• Neurologic Diseases;

• Neoplastic Diseases;

• Recent myocardial infarction or cardiac surgery (less than 6 months);

• Unstable angina pectoris;

• Atrial Fibrillation;

• Pacemakers users;

• Changing medication or hospital admission.

Related Conditions & MeSH terms

• Heart Failure

Intervention

Other:
• Aerobic Exercise Training

Locations

Country	Name	City	State
Brazil	Heart Institute (InCor), University of Sao Paulo Medical School	Sao Paulo

Sponsors (3)

Lead Sponsor	Collaborator
University of Sao Paulo General Hospital	Conselho Nacional de Desenvolvimento Científico e Tecnológico, Fundação de Amparo à Pesquisa do Estado de São Paulo

Country where clinical trial is conducted

Brazil, 

References & Publications (1)

Unable to connect to PubMed to validate , last attempt on June 19, 2013 at 12:03 PM EDT

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Autonomic Control	Mechanoreceptors were activated by passive exercise and metaboreceptors by post-exercise circulatory arrest	4 months
Primary	Muscular Evaluation	Muscular evaluation will be done by muscle gene expression	4 months
Secondary	Functional Capacity	Functional Capacity will be determined by cardiopulmonary exercise testing	4 months
Secondary	Muscle Blood Flow	Forearm blood flow will be assessed by venous occlusion plethysmography	4 months
Secondary	Blood Pressure	Blood pressure will be monitored non-invasively	4 months