Heart Failure Clinical Trial
Official title:
Urocortins 2 & 3-Effects on Forearm Arterial Blood Flow in Patients With Heart Failure
Despite modern advances in treatment, heart failure continues to carry a poor prognosis with
high morbidity and mortality rates. Hence, there remains a major interest in the development
of novel therapeutic agents for this debilitating condition. Urocortins have recently shot
into limelight with their potential role in the pathophysiology and treatment of heart
failure.
Recent studies by the investigators group (REC no: 09/S1103/41) have confirmed that
Urocortin 2 and 3 are potent arterial vasodilators, the effects of which are reproducible
and well tolerated in healthy male volunteers. Previous studies using heart failure models
in animals1-7, as well studies in heart failure patients (Urocortin 2), suggest that there
is great scope for Urocortins as novel biomarkers and as potential therapeutic agents in
heart failure. With this in mind, the investigators wish to study the local vasomotor
effects of these peptides in greater detail in patients with heart failure.
n/a
Allocation: Non-Randomized, Endpoint Classification: Pharmacodynamics Study, Intervention Model: Parallel Assignment, Masking: Single Blind (Subject), Primary Purpose: Basic Science
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