Heart Failure Clinical Trial
Official title:
Preoperative Parenteral Thiamine Supplementation in Patients Undergoing Heart Surgery - a Pilot Study
Verified date | February 2021 |
Source | Medical University of Vienna |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Interventional |
The objective of this study is to determine whether preoperative parenteral thiamin supplementation does prevent the intra and early postoperative increase of lactate and whether this effect is related to the extent of thiamine deficiency in patients undergoing heart surgery. In addition the prevalence of major thiamin deficiency in patient undergoing heart surgery will be determined.
Status | Completed |
Enrollment | 30 |
Est. completion date | February 2, 2015 |
Est. primary completion date | February 1, 2015 |
Accepts healthy volunteers | No |
Gender | All |
Age group | 18 Years and older |
Eligibility | Inclusion Criteria: - age 18 - 100 years - planned heart surgery - signed informed consent Exclusion Criteria: - pregnancy and lactation - known allergic reaction to the drugs used - mental condition rendering the patient unable to give informed consent - inability or contraindications to perform study procedures |
Country | Name | City | State |
---|---|---|---|
Austria | Medical University Vienna | Vienna |
Lead Sponsor | Collaborator |
---|---|
Medical University of Vienna |
Austria,
Luger M, Hiesmayr M, Köppel P, Sima B, Ranz I, Weiss C, König J, Luger E, Kruschitz R, Ludvik B, Schindler K. Influence of intravenous thiamine supplementation on blood lactate concentration prior to cardiac surgery: A double-blinded, randomised controlle — View Citation
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Thiamine status and lactate levels | Thiamine status: functional parameter - erythrocyte transketolase (a-ETK) expressed as TPP (thiamine pyrophosphate); quantity of vitamin B1 in urine and blood concentrations Lactate levels: lactate levels will be determined by blood gas analysis (BGA) within the routine check. | perioperative | |
Secondary | Prevalence of thiamine deficiency, identification of body composition and length of hospital and ICU stay | Thiamine status: functional parameter - erythrocyte transketolase (a-ETK) expressed as TPP (thiamine pyrophosphate); Body composition: measuring with bioelectrical impedance analysis (BIA) Length of ICU and hospital stay; | 2-3 weeks |
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