Heart Failure Clinical Trial
Official title:
Acute Effect of Continuous Positive Airway Pressure on Left Ventricular Diastolic Function and Exercise Tolerance in Compensated Heart Failure
Acute effects of CPAP on diastolic function in patients with compensated heart failure (CHF)
are unknown. The investigators hypothesized that acutely CPAP improves diastolic function,
which is associated with increases exercise tolerance.
Objective: To evaluate the acute effects of CPAP on functional capacity and diastolic
indices of patients with CHF. This is a randomized trial including 44 patients with
compensated heart failure (functional classes II or III, NYHA). Patients will be allocated
in CPAP(CPAP with 10cmH2O) or simulated CPAP (null pressure) after computed randomization,
in a 1:1 ratio. All subjects shall complete a 6-minute walk test (6MWT) before and after
CPAP (30 minutes; 10 cm H2O pressure). Doppler-echocardiogram will be performed before and
at the end of CPAP. Wilcoxon or paired t tests were used to compare results, with
significance level at p < 0.05.
n/a
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Single Blind (Subject), Primary Purpose: Diagnostic
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