Heart Failure Clinical Trial
Official title:
Developing an Improved Measure of Chemosensitivity for the Study of Periodic Breathing in Heart Failure: the Cyclocapnic Method
We aim to test our method for measuring chemosensitivity (the ventilatory response to a
change in carbon dioxide), which uses sinusoidal carbon dioxide stimuli.
Hypotheses:
- Carbon dioxide sensitivity is dependent on the cycle time over which we administer the
gas (frequency).
- Chemoreflex gain decreases as deadspace increases.
Status | Recruiting |
Enrollment | 45 |
Est. completion date | October 2010 |
Est. primary completion date | April 2010 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | Male |
Age group | 18 Years to 80 Years |
Eligibility |
Inclusion Criteria: - Heart failure subjects with stable cardiorespiratory control to be recruited from our institution's specialist heart failure clinic. - Normal healthy volunteers, with normal systolic function. Exclusion Criteria: - We will exclude patients with chronic respiratory disease (every patient will have formal lung function testing on entrance into the study) or unstable coronary artery disease (myocardial infarction or unstable angina within the past 3 months). - In addition any subjects receiving treatment with morphine and derivatives, theophylline, oxygen, benzodiazepines or acetazolamide will be excluded as these affect chemosensitivity. |
Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Basic Science
Country | Name | City | State |
---|---|---|---|
United Kingdom | St Mary's Hospital | London |
Lead Sponsor | Collaborator |
---|---|
Imperial College London |
United Kingdom,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Chemoreflex gain as measured by cyclocapnic method | every minute | No |
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