Heart Failure Clinical Trial
Official title:
Renal Effects of Levosimendan in Patients Admitted With Acute Decompensated Heart Failure
The purpose of this study is to evaluate the effect of levosimendan infusion, in addition to standard therapy,on renal function in patients with Acute Heart Failure,compared with standard therapy alone.
The term "cardiorenal syndrome" has been applied to the presence or development of a renal
dysfunction in HF patients and may be the major precipitant of decompensation and cause for
admission in these patients. The renal hypoperfusion that occurs with cardiac injury can
lead to sodium and water retention and activation of the renin-angiotensin-aldosterone
system and neurohormonal pathways with resultant deleterious effects on the myocardium. A
vicious cycle may then ensue and be associated with increased cardiovascular complications.
In this regard, renal dysfunction is of a functional nature and thus means to intervene with
this vicious cycle need to be sought.
Several studies already demonstrated the deleterious effects of renal dysfunction on
prognosis in patients with HF due to chronic left ventricular dysfunction.
Levosimendan increases myocardial contractility without significant changes in the
intracellular calcium ion and cyclic adenosine monophosphate concentrations and does not
enhance myocardial oxygen demand. By its action on the potassium channels this drug also
dilates the coronary and peripheral arteries and exerts an anti-ischemic,anti-stunning
effect. To date, the effects of levosimendan on renal function in patients with worsening
chronic HF, remain unknown.
;
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment
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