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SGLT2i and KNO3 in HFpEF - The SAK HFpEF Trial

Heart Failure With Preserved Ejection Fraction Clinical Trial

Official title:
SGLT2i and KNO3 in HFpEF - The SAK HFpEF Trial

Clinical Trial Summary

This study will test whether pharmacologic agents that may improve mitochondrial function and energy fuel metabolism [Empagliflozin (Empa)], with and without additional supplements that increase perfusion and fatty acid oxidation [Potassium Nitrate (KNO3)], improve submaximal exercise endurance and skeletal muscle oxidative phosphorylation capacity (SkM OxPhos) in participants with Heart Failure with Preserved Ejection Fraction (HFpEF).

Clinical Trial Description

This study will test whether Empagliflozin (Empa), with and without Potassium Nitrate (KNO3), improves submaximal exercise endurance, skeletal muscle oxidative phosphorylation capacity (SkM OxPhos), intramuscular perfusion, and changes in the skeletal muscle metabolome, proteome, and respiration in participants with Heart Failure with Preserved Ejection Fraction (HFpEF). ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT05138575
Study type Interventional
Source University of Pennsylvania
Contact Gabrielle Grosso
Phone 267-776-3138
Email Gabrielle.Grosso@Pennmedicine.upenn.edu
Status Recruiting
Phase Phase 2
Start date January 24, 2022
Completion date March 1, 2026
View Details
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