Remifentanil & Glycemic Response in Cardiac Surgery

Status Completed

Clinical Trial Summary

This study evaluates the effect of using remifentanil during cardiopulmonary bypass surgery to supress the hyperglycemic response in perioperative period. Half of the participants will receive continuous intravenous remifentanil during surgery, while the other half will receive intermittent intravenous fentanyl during surgery. Intermittent intravenous fentanyl administration is this institution's standard of care.

Clinical Trial Description

Stress-induced hyperglycemia is a well-known phenomena that occurs during cardiopulmonary bypass surgery. Hyperglycemia increases the incidence of major adverse events and mortality in patients undergoing cardiac surgery.

Remifentanil, an ultra-short acting opioid analgesic, has been shown to reduce the stress response to cardiopulmonary bypass when compared to intermittent fentanyl and inhalation anesthesia. This in turn, will reduce the occurence of perioperative hyperglycemia, glycemic variability and insulin requirements in patients undergoing cardiac surgery.

NOTE;

Primary Outcome changed on 06/15/2015-Change Approved by University of Pittsburgh IRB on 06/22/2015- First patient enrolled January 2016.

Primary outcome measure; Percentage of patients with two or more than two intraoperative blood glucose levels more than 180 mg% in both groups will be estimated and the difference in this parameter between the two groups will form the primary outcome measure of this study. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT02349152
Study type	Interventional
Source	University of Pittsburgh
Contact
Status	Completed
Phase	Phase 4
Start date	January 2016
Completion date	December 2017

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Remifentanil and Glycemic Response in Cardiac Surgery

Clinical Trial Summary

Clinical Trial Description

Study Design

Related Conditions & MeSH terms