Heart Diseases Clinical Trial
Official title:
Assessment of Relationship Between Acute Ischemic Stroke and Heart Disease
Although cardio-embolic etiology of ischemic stroke (IS) is largely respected, there is still
no clear recommendation for routine complex cardiological examination in all IS patients.
Using complex cardiological examination the investigators expect:
1. more accurate detection of patients with concomitant heart disease (cardiac rhythm
disorder, valve disorders, acute coronary syndrome, cardiac thrombus and myxoma, atrial
and ventricle septum defects)
2. higher number of etiologically determinated IS, which is crucial for accurate secondary
prevention.
The investigators expect significant changes of biochemical parameters (NT pro B-type of
natriuretic peptide, pro-atrial natriuretic peptide, creatinkinase MB, troponin T),
inflammatory markers (interleukine 6, procalcitonin, high sensitive C-reactive protein), and
coagulation parameters in patients with CE IS compared to other causes of IS.
Assessing the glomerular filtration of cystatin C, glycated haemoglobin and serum lipids and
its correlation with prior medicament use will allow to evaluate the long-term compensation
of arterial hypertension, diabetes mellitus and dyslipidemia in IS patients.
In addition to the above mentioned comprehensive cardiological examinations, 1- and 3-week
ECG-Holter will be performed in subpopulation of patients old up to 50 years and with
cryptogenic ischemic stroke in the period from 1st May 2013 to 31st December 2015. These
patients will also fill in a special epidemiologic questionnaire. Anticipated enrollment in
this substudy of HISTORY study is 40 - 80 patients.
In selected young cryptogenic stroke patients, a subcutaneous cardiac monitor was implanted
for the detection of paroxysmal atrial fibrillation in the period from 1st January 2014 to
31st December 2015.
From 2016 in young ischemic stroke (IS) patients under 50 years, a standard
perfusion/ventilation scintigraphy of lungs will be performed to exclude acute pulmonary
embolization (coincidental) in case of elevated serum D-dimers after admission.
In all enrolled young IS patients, a BP Holter will be performed after the discharge home to
exclude possible arterial hypertension, which did not presented during hospitalization.
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