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Heart-Assist Device clinical trials

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NCT ID: NCT05408104 Completed - Heart Failure Clinical Trials

Postoperative Tolvaptan Use in Left Ventricular Assist Device Implantation Patients

TOLVAD
Start date: March 28, 2019
Phase:
Study type: Observational

This research study will compare two standard of care approaches for managing low sodium levels in heart failure patients with Left Ventricular Assist Device (LVAD). The study will compare the outcomes of LVAD patients with low sodium levels who take Tolvaptan to those who do not take Tolvaptan. Tolvaptan is FDA approved for use in the study population and is commonly used to treat low sodium levels in heart failure and LVAD patients. It is not known if taking Tolvaptan or not taking Tolvaptan is better at improving outcomes in newly implanted LVAD patients with low sodium levels. By doing this study, the Principal Investigator (PI) hopes to learn which is better at improving outcomes.

NCT ID: NCT03409627 Completed - Heart Failure Clinical Trials

Novel INXN-4001 Triple Effector Plasmid in Heart Failure

Start date: April 9, 2018
Phase: Phase 1
Study type: Interventional

To evaluate the safety of retrograde coronary sinus infusion (RCSI) of a novel triple-effector plasmid (INXN-4001) in outpatient LVAD recipients as assessed by incidence of all study intervention-related adverse events occurring up to 6 months post-RCSI (primary endpoints), and to evaluate general safety by assessing incidence of cardiac specific adverse events and the incidence of related serious adverse events at intervals up to 12 months post-infusion (or until cardiac transplantation or death).

NCT ID: NCT03004066 Completed - Heart Assist Device Clinical Trials

Daptomycin Concentration in Drainage Fluid and Blood Samples of ICU Patients

Start date: October 2016
Phase:
Study type: Observational

10 patients with chronic heart failure receiving daptomycin therapy after implantation of a left ventricular heart assist system. Measurement of daptomycin levels in drainage fluids (mediastinal and pleural drainage systems) and in blood samples.