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Clinical Trial Details — Status: Not yet recruiting

Administrative data

NCT number NCT06431334
Other study ID # A06-M25-23A
Secondary ID
Status Not yet recruiting
Phase N/A
First received
Last updated
Start date May 2024
Est. completion date January 2025

Study information

Verified date May 2024
Source McGill University
Contact Tyler A. Churchward-Venne, Ph.D.
Phone (514) 398-4184
Email tyler.churchward-venne@mcgill.ca
Is FDA regulated No
Health authority
Study type Interventional

Clinical Trial Summary

Masters level cyclists are a population above the age of 35 years who frequently participate in prolonged as well as heavy-volume training. Like most endurance-trained athletes, a greater recommended dietary allowance (RDA) for protein of 1.2-1.4 g/kg/bw is suggested. Dietary protein intake is vital for maximizing the benefits of training and ensuring optimal recovery. Dietary recommendations traditionally have been determined through nitrogen balance techniques, however, recent research indicates how this method is potentially underestimating protein requirements. Therefore, there is a need to reassess current dietary recommendations in order to meet the demands of physical activity for highly active populations. Recent efforts to understand protein requirements during rest and following exercise have been completed using the indicator amino acid technique (IAAO). This non-invasive method is reported to provide a robust measure of protein requirements. However, there is limited work in older (≥60 years) active populations. The purpose of this study is to measure the protein requirements in master cyclists, following an endurance training session, using the non-invasive IAAO technique.


Recruitment information / eligibility

Status Not yet recruiting
Enrollment 8
Est. completion date January 2025
Est. primary completion date December 2024
Accepts healthy volunteers Accepts Healthy Volunteers
Gender Male
Age group 65 Years and older
Eligibility Inclusion Criteria: - 18.5< BMI <35 kg/m^2 - Overtly healthy masters level cyclists =65 years - Masters level cyclist training (>4 days per week; ~100 km per week) - Body mass stable over previous 6-months - Availability for multiple metabolic trials (~7 trials) - Ability to travel to and from laboratory facility Exclusion Criteria: - Recent history of weight loss or weight gain (>5% body weight) - Uncontrolled hypertension - =2 chronic diseases (e.g. diabetes, osteoporosis, dyslipidemia) - Acute illness that could affect protein metabolism (HIV, renal dysfunction, influenza) - Currently using anti-inflammatory medications - Inability to adhere to study protocol (i.e., alcohol, caffeine, dietary restrictions) - Regular tobacco user - Illicit drug use - Habitually ingesting =3 g/kg/bw

Study Design


Related Conditions & MeSH terms


Intervention

Dietary Supplement:
Amino Acid Intake
Amino acid intakes will vary between 0.5 to 2.8 g/kg/d

Locations

Country Name City State
Canada McGill University Montréal Quebec

Sponsors (1)

Lead Sponsor Collaborator
McGill University

Country where clinical trial is conducted

Canada, 

Outcome

Type Measure Description Time frame Safety issue
Primary 13CO2 Excretion Measured by continuous-flow isotope ratio mass spectrometry 7-weeks
Secondary L[13C]phenylalanine Oxidation Measured by gas chromatography-mass spectrometry 7-weeks
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