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Reducing Fatigue With CoQ10 Supplementation in Patients With Crohn's Disease Study

Healthy Clinical Trial

Official title:
Reducing Fatigue With CoQ10 Supplementation in Patients With Crohn's Disease Study

Clinical Trial Summary

This study includes an open label clinical trial comparing two doses of CoQ10 for 8 weeks to improve fatigue among patients with Crohn's disease and a prospective cohort study of healthy controls taking CoQ10 for 2 weeks. Additionally, among 15 participants who do not meet the fatigue threshold for the open label trial, the investigators will measure CoQ10 levels in blood and fasting urine, as well as complete the same data collection. Hypotheses 1. Fatigue will improve with CoQ10 and there will be a dose response with greater improvement with higher dose as measured by the Patient Reported Outcomes Measurement Information Systems Fatigue PROMIS Fatigue 7a instrument. 2. Fatigue will improve when measured with other fatigue scales in a similar dose dependent manner and that general and physical fatigue will improve more than mental fatigue. 3. CoQ10 will improve quality of life as measured with the short Inflammatory Bowel Disease Questionnaire (sIBDQ).

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT06419335
Study type Interventional
Source University of Pennsylvania
Contact Brittaney Bonhomme
Phone 2158982625
Email bobrit@pennmedicine.upenn.edu
Status Not yet recruiting
Phase Early Phase 1
Start date June 1, 2024
Completion date December 1, 2025
View Details
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