BCAAs, Muscle Protein Synthesis and Glucose Uptake

Healthy Clinical Trial

Official title:

The Role of Branched-chain Amino Acids (BCAAs) in the Stimulation of Skeletal Muscle Protein Synthesis and Glucose Uptake in Healthy Young Volunteers

Clinical Trial Details — Status: Recruiting

Administrative data

• NCT number: NCT06218264
• Other study ID #: NL82984.028.23
• Status: Recruiting
• Phase: N/A
• Start date: January 10, 2024
• Est. completion date: December 31, 2025

Study information

• Verified date: January 2024
• Source: Wageningen University
• Contact: Marlou Dirks, PhD
• Phone: +31 317 480 100
• Email: marlou.dirks[@]wur.nl
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

The present study aims to quantify the insulin sensitivity and the skeletal muscle protein synthetic response to consuming a test drink containing all amino acids or all amino acids except for BCAAs.

Description:

Twenty-eight healthy, young volunteers will receive a stable isotope tracer infusion (7.5h) combined with repeated blood and muscle sampling, to measure muscle protein synthesis rate in the postabsorptive state following ingestion of a drink containing all amino acids (n=14) or all amino acids except for BCAAs (n=14).

Recruitment information / eligibility

• Status: Recruiting
• Enrollment: 28
• Est. completion date: December 31, 2025
• Est. primary completion date: December 31, 2025
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 18 Years to 35 Years

Eligibility

Inclusion Criteria:

• Aged from 18-35 years

• 18.5 < Body mass index < 30 kg·m2

• Recreationally active (performing non-competitive physical exercise at least one time per week for minimally 30 minutes)

Exclusion Criteria:

• Smoking

• Diabetes (Type 1, Type 2, or genetic form of diabetes)

• Any diagnosed cardiovascular (heart) disease or high blood pressure (=140 mmHg systolic and/or =90 mmHg diastolic)

• Chronic use of any prescribed or over the counter pharmaceuticals (excluding oral contraceptives and contraceptive devices)

• Known allergy to lidocaine

• Regular use of dietary protein and/or amino acid supplements (>3 times per week)

• Currently involved in a structured progressive resistance training programme (>3 times per week)

• A personal or family history of thrombosis (clots), epilepsy, seizures, or schizophrenia.

• Any previous motor disorders or disorders in muscle and/or lipid metabolism

• Presence of an ulcer in the stomach or gut and/or strong history of indigestion

• Known severe kidney problems

• Pregnant or breastfeeding

• Unable to give consent

Related Conditions & MeSH terms

• Healthy

Intervention

Dietary Supplement:
• Ingestion of an amino acid supplement
Oral intake of a supplement containing amino acids

Locations

Country	Name	City	State
Netherlands	Wageningen University and Research	Wageningen	Gelderland

Sponsors (1)

Lead Sponsor	Collaborator
Wageningen University

Country where clinical trial is conducted

Netherlands, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Postprandial muscle protein synthesis	Muscle protein synthesis rate (FSR) prior to and following ingestion of an amino acid drink	4 hours
Secondary	Forearm muscle glucose uptake	Insulin sensitivity, measured as forearm glucose uptake, prior to and following ingestion of an amino acid drink	7.5 hours
Secondary	Whole-body insulin sensitivity	Whole-body insulin sensitivity, calculated using a modified Matsuda index	Four hours following ingestion of an amino acid drink
Secondary	Forearm amino acid kinetics	Plasma phenylalanine kinetics using a stable isotope tracer infusion	Prior to and for 4 hours following amino acid intake