Charcot-Marie-Tooth Disease (CMT) Biological Sample Collection for iPSC Generation and Biobanking

Healthy Clinical Trial

Official title:

Charcot-Marie-Tooth Disease (CMT) Biological Sample Collection for iPSC Generation and Biobanking

Clinical Trial Details — Status: Recruiting

Administrative data

• NCT number: NCT06203093
• Other study ID #: 10-009
• Status: Recruiting
• Start date: September 22, 2022
• Est. completion date: September 22, 2025

Study information

• Verified date: January 2024
• Source: New York Stem Cell Foundation Research Institute
• Contact: Becca Wood
• Phone: 212-927-1801
• Email: clinicalresearch[@]nyscf.org
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

The New York Stem Cell Foundation (NYSCF) Research Institute is performing this research to accelerate Charcot-Marie-Tooth disease research and drug development by using cells from the body (such as skin or blood cells) to make stem cells and other types of cells, conduct research on the samples, perform genetic testing, and/or store the samples for future use. Through this research, researchers hope to identify future treatments or even cures for Charcot-Marie-Tooth disease.

Description:

Researchers at the New York Stem Cell Foundation (NYSCF) Research Institute study diverse diseases, conditions, and traits by creating stem cells from biological samples. These "pluripotent" stem cells can become any cell in the human body, including cells that may be difficult, invasive, or impossible to obtain directly. Additionally, researchers perform genetic testing to learn more about DNA, a material in most cells that contains instructions for the body's development and functions (such as traits like eye color and risk of certain diseases). A piece of DNA that determines the specific role of a cell is called a "gene." If the instructions in a gene are abnormal, this can lead to disease. Participation in the study involves: (1) completion of health questionnaires, (2) providing a skin and/or blood sample from which stem cells may be created, (3) collection of a saliva sample for genetic analysis, and (4) possible future followup to provide additional information or learn about other research studies. This study is not a clinical trial.

Recruitment information / eligibility

• Status: Recruiting
• Enrollment: 50
• Est. completion date: September 22, 2025
• Est. primary completion date: September 22, 2025
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 5 Years and older

Eligibility

Inclusion Criteria:

• Age 5 years or older.
• Diagnosis of Charcot-Marie-Tooth (CMT) disease or healthy controls.
• Adults must provide written informed consent unless physical limitations preclude signing.
• Minors undergoing skin collection for research purposes must have a CMT diagnosis and must participate with parent/guardian consent.
• Minors undergoing blood and/or saliva collection for research purposes or who transfer biological samples from a procedure outside the research may have a CMT diagnosis or serve as a healthy control and may participate with parent/guardian consent.

Exclusion Criteria:

• Wards of the state.
• For prospective skin samples: history of keloid formation, coagulation disorder, allergy to the anesthetic, or anticoagulation use that precludes sample collection.
• For prospective blood samples: coagulation disorder or other medical conditions that increase the risks associated with blood collection.
• For all prospective sample collections: Subjects who refuse to adhere to NYSCF's and/or a collaborating site's safety protocols will be excluded. Subjects with an AIDS diagnosis and CD4 count of less than 200 cells per microliter of blood will be excluded due to increased risk of infection.

Related Conditions & MeSH terms

• Charcot-Marie-Tooth Disease
• Healthy
• Hereditary Sensory and Motor Neuropathy
• Nerve Compression Syndromes
• Tooth Diseases

Intervention

Other:
• Biological Sample Collection
Skin biopsy (2-3mm) and/or blood (up to 50mL); saliva; excess/leftover biospecimens that were (or will be) collected for other purposes (e.g., medical procedure).

Locations

Country	Name	City	State
United States	New York Stem Cell Foundation Research Institute	New York	New York

Sponsors (2)

Lead Sponsor	Collaborator
New York Stem Cell Foundation Research Institute	Charcot-Marie-Tooth Association

Country where clinical trial is conducted

United States, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Biobank	Establishment of a bank of stem cell lines and associated information to advance understanding of the biology, etiology, manifestations, progression, risk factors, genetic underpinnings, and treatment of Charcot-Marie-Tooth diseases.	Baseline