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Dose-Dependent Effect of Intranasal Insulin in Humans Using Functional Magnetic Resonance Imaging (fMRI)

Healthy Clinical Trial

Official title:
Phase 1, Dose-Dependent Effect of Intranasal Insulin in Humans Using Functional MRI

Clinical Trial Summary

The purpose of this trial is to study the brain response using functional MRI (fMRI) before and after varying doses of insulin given through the nose. The magnetic resonance imaging uses a very strong magnet to produce images of participant's brain. It becomes a functional MRI when the study team looks at the activity within the brain (blood flow / change in metabolism).

Clinical Trial Description

If cardiac arrest is not treated immediately, it causes sudden death. Intranasal insulin may be a way to prevent the brain injury that occurs after a cardiac arrest or other brain injury. Even when immediate treatment gets the heart beating again, many victims remain comatose and die later from brain injury. Nasal insulin reduces brain injury in animal experiments and has been used to try to improve brain degeneration in patients with Alzheimer's disease in doses up to 160 units. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT06144255
Study type Interventional
Source University of Michigan
Contact
Status Completed
Phase Phase 1
Start date November 17, 2023
Completion date February 22, 2024
View Details
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