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RECOVERS - Realigning Emotion and COgnition Via prEcision Regulation networkS

Healthy Clinical Trial

Official title:
RECOVERS - Realigning Emotion and COgnition Via prEcision Regulation networkS - Phase I Study: Multimodal Computational Modeling of Cognitive Flexibility and Emotion Regulation Networks

Clinical Trial Summary

In this research study, the investigators are using examining how brain activity (electrical and blood flow) changes during tests of emotional processing and attention and memory in the magnetic resonance imaging (MRI) scanner. Investigators are also using non-invasive brain stimulation to probe different parts of the brain and measuring brain activity (electrical and blood flow). This study includes healthy participants and researchers hope this will help us develop improved brain-based treatments for emotional difficulties like depression.

Clinical Trial Description

Investigators hypothesize that targeted neuroplastic changes induced by individually-tailored rTMS will substantially reduce clinical symptoms underlying depression, anxiety and suicidality, and in general, revolutionize non-invasive treatments of mental health disorders. Investigators hypothesize that functional coupling in cognitive flexibility (CF) and emotion regulation (ER) networks is indexed by the phase of the brain's alpha oscillations. Using a novel integrated instrument that enables simultaneous functional magnetic resonance imaging (fMRI), electroencephalography (EEG) and transcranial magnetic stimulation (TMS), investigators propose to identify individualized stimulation parameters that reflect the strongest coupling of the CF/ER networks. The neuromechanistic model further posits that by applying repetitive TMS (rTMS) with these individualized parameters, one can induce entrainment in brain networks that drive neuroplastic changes in CF and ER. This initial Phase I Task 3 sub-study is a proof-of-principle study in healthy control participants. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT05977439
Study type Observational
Source Medical University of South Carolina
Contact Jacob McTeague, PhD
Phone 843-792-8274
Email MCTEAGUE@MUSC.EDU
Status Recruiting
Phase
Start date February 1, 2024
Completion date October 1, 2028
View Details
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