Healthy Clinical Trial - Mechanisms of Exercise-induced Hypoalgesia

Status Recruiting

Clinical Trial Summary

This project aims to clarify the mechanisms underpinning the acute analgesic effect of exercise in healthy humans-a phenomenon called "Exercise-induced hypoalgesia" (EIH). This study will characterize, using a within-subject cross-over design, the effects of a single session of aerobic exercise vs. a control condition on the sensitivity to stimuli preferentially activating mechano vs. heat-sensitive nociceptors of the skin vs. muscle, within vs. outside exercising body parts. The investigators hypothesize (1) that EIH will be greater in the exercise session compared to the control session, (2) that EIH will be greater at the local site compared to the remote site if local changes in nociceptive sensitivity contribute to EIH, and (3) that exercise will preferentially affect blunt pressure-induced pain if EIH involves specific changes in sensitivity of muscle nociceptors.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT05961449
Study type	Interventional
Source	Université Catholique de Louvain
Contact	Vladimir Aron, Msc, PT
Phone	0032494053325
Email	vladimir.aron@uclouvain.be
Status	Recruiting
Phase	N/A
Start date	April 26, 2023
Completion date	September 1, 2023

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