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Development of Non-invasive Methods to Study Gut Microbiome - Nutrition - Host Interactions

Healthy Clinical Trial

Official title:
Development of Non-invasive Methods to Study Gut Microbiome - Nutrition - Host Interactions

Clinical Trial Summary

The aim of this study is to develop and validate an adequate protocol of volatolome (volatile metabolites) measurement in breath of human volunteers (18-65 years) to study gut microbiome - nutrition - host interactions in a general healthy population. For this purpose, breath volatile metabolites (BVM) will be analyzed throughout test days in fasting state and after standardized meals using selected ion flow tube mass spectrometry (SIFT-MS). In addition, gut microbial functions linked notably to hydrogen/methane production, carbohydrates utilization (CAZymes), and in the production of other volatile metabolites of interest (i.e. indole, fatty acid derivatives, ...) will be unraveled through microbiome sequencing data analysis (in silico), metabolomic analyses and measurement of enzymatic activities from saliva, urine and/or fecal samples.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT05949411
Study type Interventional
Source Université Catholique de Louvain
Contact Nathalie Delzenne, Prof.
Phone 0032 2 764 73 69
Email nathalie.delzenne@uclouvain.be
Status Recruiting
Phase N/A
Start date July 1, 2023
Completion date December 31, 2024
View Details
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