Spectral Characteristics of Memory Transformation

Healthy Clinical Trial

— MEM_MOD  

Official title:

Probing Mechanisms of Procedural Memory Transformation With Cross-frequency Transcranial Alternating Current Stimulation (Cf-tACS) as an Avenue to Sculpt Sensorimotor Behavior

Clinical Trial Details — Status: Recruiting

Administrative data

• NCT number: NCT05946616
• Other study ID #: 00126392
• Status: Recruiting
• Phase: N/A
• Start date: July 1, 2023
• Est. completion date: March 31, 2024

Study information

• Verified date: July 2023
• Source: Medical University of South Carolina
• Contact: Kirstin-Friederike Heise, PhD
• Phone: (843)792-
• Email: heisek[@]musc.edu
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

Sometimes, it is necessary to re-learn a previously learned movement behavior, for example, a bad posture during the golf drive or while playing the piano. Unlearning or relearning an intensively trained behavior is particularly important if the behavior is hampering recovery, for example, in chronic pain or after a stroke. With this pilot study, the brain mechanisms that control the change of pre-existing stable memories of a motor skill will be tested with electroencephalography (EEG). Non-invasive brain stimulation will be used to modulate these brain mechanisms and test if it is possible to change the pre-existing motor memory and the learning of a new motor skill.

Recruitment information / eligibility

• Status: Recruiting
• Enrollment: 30
• Est. completion date: March 31, 2024
• Est. primary completion date: March 31, 2024
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 18 Years and older

Eligibility

Inclusion Criteria:

• Age 18 years or older (2/3 of the final sample will be =60years of age)

• No previous stroke, brain tumor, neurodegenerative disease, or trauma to the head

• Ability to give consent for study participation

• who have access to a personal computer with internet

Exclusion Criteria:

• • Pregnancy

• Inability to use all ten fingers to type on a standard computer keyboard

• Uncorrected vision, hindering perception of visual cues presented on a standard computer screen

• Medication use at the time of study that may interfere with learning or the effect of tACS, including but not limited to carbamazepine, flunarizine, sulpiride, rivastigmine, dextromethorphan;

• Neuromuscular disorders affecting hand and finger movements necessary for 10-finger keyboard typing

• Presence of neurological or psychiatric disorders

• Presence of scalp injury or disease

• Prior history of seizures

• Prior intracranial surgery

• Prior brain radiotherapy

• Prior history of intracranial tumor, intracranial infection, or cerebrovascular malformation

• Metal in head or neck

• Contraindications to MRI (such as severe claustrophobia, implanted medical devices)

Related Conditions & MeSH terms

• Healthy

Intervention

Other:
• Transcranial alternating current stimulation (tACS) combined with behavioral intervention
Transcranial alternating current stimulation (tACS) combined with behavioral intervention (memory interference).
• Inactive (sham) stimulation combined with behavioral intervention
Inactive (sham) stimulation combined with behavioral intervention (memory interference)

Locations

Country	Name	City	State
United States	Medical University of South Carolina	Charleston	South Carolina

Sponsors (1)

Lead Sponsor	Collaborator
Medical University of South Carolina

Country where clinical trial is conducted

United States, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Behavioral: interference rate	Change in performance precision of a previously learned sensorimotor skill	before - after one single intervention (1 hour)
Primary	Neural: brain connectivity change	Change in EEG-derived markers of brain activation and connectivity	before - after one single intervention (1 hour)
Secondary	Behavioral: interference rate	Change in performance precision of a previously learned sensorimotor skill	before - after one single intervention (24 hour follow-up)
Secondary	Neural: brain connectivity change	Change in EEG-derived markers of brain activation and connectivity	before - after one single intervention (24 hour follow-up)