Healthy Clinical Trial
Official title:
Impact of Formulation on the Pharmacokinetics of Micropatch-assisted Delivery of Metronidazole
This is a crossover pharmacokinetic clinical study in healthy volunteers to compare metronidazole delivery through skin when a gel or cream metronidazole product is applied to skin treated with a micropatch.
The goal of this crossover pharmacokinetic clinical study in healthy volunteers is to compare metronidazole delivery through skin when a gel or cream metronidazole product is applied to skin treated with a micropatch. The main questions this study aims to answer are: - Is micropatch transdermal delivery dependent on the metronidazole product formulation? - Is transdermal delivery dependent on micropore lifetime of the skin after micropatch application? Participants will be divided into groups based on metronidazole product (gel or cream). - The metronidazole product will be applied to micropatch-treated skin in study period one. Measurements of the skin barrier will be made before and after micropatch treatment. - Daily blood samples will be collected for up to 5 days after the micropatch and metronidazole are first applied. - Following a one-week washout period, the same study process will be repeated except that metronidazole product will be applied to skin without micropatch pretreatment. ;
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