Prefrontal iTBS on Working Memory

Healthy Clinical Trial

Official title:

Exploring the Effects of Prefrontal iTBS on Working Memory in Healthy Participants: a Concurrent TMS/fNIRS Study

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT05774223
• Other study ID #: HSEARS20200120005-03
• Status: Completed
• Phase: N/A
• Start date: March 1, 2023
• Est. completion date: June 15, 2023

Study information

• Verified date: June 2023
• Source: The Hong Kong Polytechnic University
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

The investigators previous pilot study showed that the brain remained activated after 3 minutes of intermittent theta burst stimulation (iTBS). Therefore, an open question remains that how long the effects will last and when the maximum effects will be achieved. In addition, many pioneering works showed the positive effects of repetitive transcranial magnetic stimulation (rTMS) on working memory. Intermittent theta burst stimulation (iTBS) is a patterned form of rTMS, it has shown a non-inferior efficacy in depression but with a much shorter time (approximately 3 mins) than traditional rTMS (approximately 40 mins).

As discussed above, this study aims to investigate the effects of prefrontal iTBS on working memory using concurrent iTBS/fNIRS and to explore the duration of the effects.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 31
• Est. completion date: June 15, 2023
• Est. primary completion date: June 15, 2023
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 18 Years to 35 Years

Eligibility

Inclusion Criteria:

• right-handed participants

• normal or corrected-to-normal vision

Exclusion Criteria:

• a current or past diagnosis of any neurological or psychiatric disorder

• any severe medical conditions, seizure, and pregnancy

• contraindication to TMS (e.g., with mental implants)

Related Conditions & MeSH terms

• Healthy

Intervention

Device:
• Transcranial magnetic stimulation (TMS)-active
Active intermittent TBS (iTBS) will be applied to the left DLPFC at 80% of the resting motor threshold (rMT) (Hoy et al., 2016). A stimulation, where 3-pulse at 50 Hz will be given, will repeat every 10 s for a total of 190 s (600 pulses in total) (Huang et al., 2005). The left DLPFC stimulation site will be determined using the neuronavigator system (lDLPFC, x-38, y+44, z+26).
• Transcranial magnetic stimulation (TMS)-sham
Sham intermittent TBS (iTBS) will be applied to the left DLPFC at 80% of the resting motor threshold (rMT) (Hoy et al., 2016). The coil will be placed perpendicular to the left DLPFC. A stimulation, where 3-pulse at 50 Hz will be given, will repeat every 10 s for a total of 190 s (600 pulses in total) (Huang et al., 2005). The left DLPFC stimulation site will be determined using the neuronavigator system (lDLPFC, x-38, y+44, z+26).

Locations

Country	Name	City	State
Hong Kong	The Hong Kong Polytechnic University	Hong Kong

Sponsors (1)

Lead Sponsor	Collaborator
The Hong Kong Polytechnic University

Country where clinical trial is conducted

Hong Kong, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	N-back	The accuracy number of each n-back task	before and post iTBS, up to 3 months
Primary	N-back	The response time of each n-back task	before and post iTBS, up to 3 months
Secondary	Hemoglobin change	The hemoglobin change throughout whole procedure.	before and post iTBS, up to 3 months