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NCT05749523 Clinical Trial

The Influence of Exercise and Hydration to the Pharmacological Response to Inhaled Terbutalin and Salbutamol in Men

Healthy Clinical Trial

Official title:
The Influence of Exercise and Hydration to the Pharmacological Response to Inhaled Terbutalin and Salbutamol in Men

Clinical Trial Details — Status: Withdrawn

Administrative data
NCT number NCT05749523
Other study ID # 2013-000483-29
Secondary ID
Status Withdrawn
Phase Phase 4
First received
Last updated
Start date November 2013
Est. completion date September 2014

Study information
Verified date February 2023
Source Bispebjerg Hospital
Contact n/a
Is FDA regulated No
Health authority
Study type Interventional

Clinical Trial Summary

To investigate the effects of dehydration and exercise for the urine secretion of beta2-agonists.

Description:

No studies have examined the influence of factors such as exercise and dehydration on the pharmacokinetic profile of asthmatic drugs (beta2-agonists). Exercise may modify the metabolism and excretion of drugs, and sweat loss during exercise can result in dehydration, both affecting the urine concentration of the drug.

Recruitment information / eligibility
Status Withdrawn
Enrollment 0
Est. completion date September 2014
Est. primary completion date April 2014
Accepts healthy volunteers Accepts Healthy Volunteers
Gender Male
Age group 18 Years to 40 Years
Eligibility Inclusion Criteria: - men - aerobic capacity more than 50ml / min / kg - more than 5h training pr week Exclusion Criteria: - smokers - allergy for the medicine - chronic diseases

Study Design

Related Conditions & MeSH terms

Intervention

Behavioral:
• Exercise
Exercise vs non-exercise

Locations
Country Name City State
Denmark Department of Respiratory Medicine, L, Bispebjerg Hospital, Copenhagen NV

Sponsors (1)
Lead Sponsor Collaborator
Vibeke Backer

Country where clinical trial is conducted

Denmark, 

Outcome
Type Measure Description Time frame Safety issue
Primary Urine concentration of salbutamol and terbutalin Urine concentration of salbutamol and terbutalin 7 days
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