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Effects of IAP-EOGBSD on Offspring's Gut Microbiome and Immunity.

Healthy Clinical Trial

Official title:
The Effects of Intrapartum Antibiotic Prophylaxis to Prevent Group B Streptococcal Early-onset Disease on Intestinal Microbiome and Immunity of Offspring

Clinical Trial Summary

This study is planned to be recruited in two hospitals in South China, Zhujiang Hospital of Southern Medical University and Zhongshan Boai Hospital Recruit participants, plan to recruit obstetrics and child health departments in study hospitals, meet inclusion and discharge criteria 1~3 infants, a total of 360, recruited by Pearl River Hospital of Southern Medical University and Zhongshan Boai Hospital 180 people each.

Clinical Trial Description

This is a case-control study. By collecting fecal samples of infants and young children in the observation group and control group at different time points (0~1 years old, 1~2 years old, 2~3 years old), the intestinal flora of infants and young children was detected by 16S rDNA sequencing, and fecal calprotectin (CP) and secretory IgA (SIgA) were detected by ELISA. To study the effects of exposure factors on intestinal flora and immunity in offspring. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT05738460
Study type Observational
Source Zhujiang Hospital
Contact
Status Active, not recruiting
Phase
Start date February 23, 2022
Completion date June 30, 2023
View Details
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