Healthy Clinical Trial
Official title:
Role of the Neurovascular System in Spontaneous Coronary Artery Dissection (SCAD)
Verified date | June 2024 |
Source | Mayo Clinic |
Contact | Pamela Engrav |
Phone | 507-255-6938 |
Engrav.Pamela[@]mayo.edu | |
Is FDA regulated | No |
Health authority | |
Study type | Interventional |
The purpose of this research is to compare sympathetic function (flight or fight system) and arterial health including structure and mechanics of participants with history of spontaneous coronary artery dissection (SCAD) to age and sex matched control participants.
Status | Recruiting |
Enrollment | 50 |
Est. completion date | August 2027 |
Est. primary completion date | August 2027 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | Female |
Age group | 18 Years and older |
Eligibility | Inclusion Criteria: - For SCAD patients: history of SCAD as confirmed by coronary angiography or cardiac computed tomography angiography - For controls: no cardiac disease history Exclusion Criteria: - Pregnancy - Known or suspected unstable cardiac condition within 4 weeks of the study - Active treatment with anticoagulation or dual antiplatelet therapy - Prisoner |
Country | Name | City | State |
---|---|---|---|
United States | Mayo Clinic Rochester | Rochester | Minnesota |
Lead Sponsor | Collaborator |
---|---|
Mayo Clinic | National Heart, Lung, and Blood Institute (NHLBI) |
United States,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Arterial thickness | Measured by carotid ultrasound intimal media thickness reporting in mm | Baseline | |
Primary | Arterial stiffness | Measured by carotid ultrasound pulse wave velocity reporting in m/s | Baseline | |
Primary | Baroreflex sensitivity | The slope between heart rate and blood pressure at rest and during the Valsalva Maneuver (ms/mmHg) | Baseline | |
Primary | Sympathetic response to stress | Blood pressure or muscle sympathetic nerve activity response to sympathoexcitatory stressors (mm/Hg or bursts/min). | Baseline |
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