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Saccharomyces Boulardii CNCM I-745 on Intestinal Barrier Function

Healthy Clinical Trial

Official title:
Effects of Saccharomyces Boulardii CNCM I-745 on Intestinal Barrier Function

Clinical Trial Summary

This study is being done to assess the effects of S. boulardii CNCM I-745 compared to placebo on impaired intestinal permeability, which is the control of material passing from inside the gastrointestinal tract through the cells lining the gut wall into the rest of the body.

Clinical Trial Description

This placebo-controlled parallel group clinical study in healthy adults from the general population aims to investigate whether oral supplementation with S. boulardii CNCM I-745 could strengthen the intestinal barrier function and counteract the acute NSAID-induced hyperpermeability. Indomethacin will be used short term to increase intestinal permeability. The primary objective of the study is to assess the effects of S. boulardii CNCM I-745 on this impaired intestinal permeability. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT05538247
Study type Interventional
Source Mayo Clinic
Contact Monique Torres
Phone 507-538-6599
Email torres.monique@mayo.edu
Status Recruiting
Phase Early Phase 1
Start date April 13, 2023
Completion date December 31, 2024
View Details
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