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The Effects of Glycerol as an Optical Clearing Agent for Visualization of the Middle Ear

Healthy Clinical Trial

Official title:
The Effects of Glycerol as an Optical Clearing Agent for Visualization of the Middle Ear

Clinical Trial Summary

This study will examine the improvement in middle ear optical coherence tomography imaging from the topical application of glycerol to the tympanic membrane in normal, opaque and post-operative ears

Clinical Trial Description

This study will explore whether the utility of Optical Coherence Tomography (OCT) in otology patients can be enhanced through the application of topical glycerol as an optical clearing agent in patients with normal, opaque and post operative tympanic membranes. In each group of subjects, a comparison will be made between OCT images obtained before and after the topical application of glycerol to the tympanic membrane and following washout with saline. Images will also be assessed for their diagnostic utility as determined by the visibility of key structures and the change in middle ear mobility caused by glycerol absorption in the tympanic membrane. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT05497934
Study type Interventional
Source Nova Scotia Health Authority
Contact Rob Adamson, PhD
Phone 1-902-497-8579
Email radamson@dal.ca
Status Not yet recruiting
Phase Phase 1
Start date October 1, 2022
Completion date March 31, 2024
View Details
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