Healthy Clinical Trial - SV2A Density Cannabis Use Disorder

Status Recruiting

Clinical Trial Summary

The main purpose of this study is to determine whether hippocampal synaptic vesicle density estimated by hippocampal [11C]APP-311/[11C]UCB-J binding in individuals diagnosed with cannabis use disorder (CUDs) improves with at least 4 weeks of confirmed abstinence from cannabis, in comparison to healthy controls (HCs). Furthermore, any change in synaptic vesicle density will be placed in functional context by measuring verbal memory, which is sensitive to hippocampal function, before and after at least 4 weeks of confirmed abstinence. Finally, the relationship between hippocampal [11C]UCB-J binding in CUDs with measures of cannabis exposure (e.g., age of initiation, cumulative lifetime dose) will be explored.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT05472818
Study type	Interventional
Source	Yale University
Contact	Anika Kumar
Phone	(203) 974-7525
Email	anika.kumar@yale.edu
Status	Recruiting
Phase	Early Phase 1
Start date	May 1, 2022
Completion date	May 2032

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