Clinical Trial Details
— Status: Completed
Administrative data
| NCT number |
NCT05451498 |
| Other study ID # |
Protocol #2021-28 |
| Secondary ID |
|
| Status |
Completed |
| Phase |
N/A
|
| First received |
|
| Last updated |
|
| Start date |
February 9, 2022 |
| Est. completion date |
May 5, 2022 |
Study information
| Verified date |
July 2022 |
| Source |
Rocky Mountain University of Health Professions |
| Contact |
n/a |
| Is FDA regulated |
No |
| Health authority |
|
| Study type |
Interventional
|
Clinical Trial Summary
While the use of creatine monohydrate supplementation and its associated benefits are well
researched and supported, the impact of the timing of when creatine is ingested is a highly
nuanced topic. The potential for the timing of administration to make an impact on observed
outcomes is an established and appreciated factor and limited research to date has examined
the impact of creatine timing. Of the literature that has been published, one study was very
short in duration (4 weeks) that possessed a study design that undermined its practicality,
two other studies used older individuals, and one study utilized a unilateral training model
which may not be an adequate exercise protocol to allow for the ergogenic potential of
creatine to mediate any enhancement of training adaptations. Therefore, based on the limited
number of studies in young and previously trained populations, future studies examining the
effects of pre vs post-training creatine monohydrate supplementation on resistance training
adaptations are warranted.
Description:
In a randomized, double-blind, placebo-controlled, parallel design, eligible study
participants were provided a daily dose of creatine monohydrate (pre-or post-workout) or
placebo (no creatine delivered) for an 8-week supplementation period. Based upon their
baseline fat-free mass, participants were randomized into one of three groups: pre-workout
creatine supplementation (PRE), post-workout creatine supplementation (POST), or placebo
(PLA). Each group consumed their assigned dose or placebo within one hour before exercise and
within one hour following exercise. Each assigned supplement was consumed with 12-16 ounces
of fluid along with a 25-gram dose of whey protein isolate and a 25-gram dose of carbohydrate
powder This additional supplementation was provided to aid in blinding and to help ensure
adequate dietary protein intake was provided to promote increases in lean body mass and
strength. Providing daily doses of carbohydrates and protein also helped with recruitment
efforts as all study participants received some efficacious nutrients.
All participants completed a twelve-week resistance training and conditioning program. The
first four weeks of resistance training (12 workouts) occurred before supplementation began
and were completed to acclimate participants to the program and to initiate early
neuromuscular adaptations commonly seen with starting a new resistance training program. In
addition, this initial 4-week period allowed for some study participants to wash out from
ongoing supplementation prior to beginning the supplementation protocol. After completion of
this run-in period, participants then completed baseline testing as described and began the
supplementation protocol while continuing to follow the resistance training program for an
additional eight weeks. Before and after the 8-week supplementation and resistance training
period, body mass, body water, and body composition were assessed in addition to changes in
muscular strength, muscular endurance, and lower-body power. All statistical analysis was
completed on data collected starting at the beginning and end of the supplementation period.
Participants were provided nutritional recommendations in order to ensure adequate energy and
protein consumption to facilitate positive training adaptations and reduce the potential
influence of differing dietary intakes.
