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Exploring the Cortical Hemodynamic Response of Excitatory Brain Stimulation: a Pilot Study

Healthy Clinical Trial

Official title:
Exploring the Cortical Hemodynamic Response of Excitatory Brain Stimulation: a Pilot Study

Clinical Trial Summary

Intermittent theta-burst stimulation (iTBS) is a promising treatment for major depressive disorder. However, fewer than 50% of patients show sufficient response. Therefore, the optimal treatment protocol is worth investigating. Recent studies show that the relationship between stimulation intensity and prefrontal hemodynamic response is not linear but in an inverse U-shape by exploring the hemodynamic changes before and after iTBS. Concurrent transcranial magnetic stimulation (TMS)/functional near-infrared spectroscopy (fNIRS) setup allows the investigators to observe the prefrontal hemodynamic response during stimulation. The aim of this study is to investigate the effects of different intensities on brain activity during and after the stimulation using fNIRS.

Clinical Trial Description

Please refer to the full proposal ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT05427552
Study type Interventional
Source The Hong Kong Polytechnic University
Contact
Status Completed
Phase N/A
Start date June 1, 2022
Completion date August 31, 2022
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