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Clinical Trial Summary

AGUEDA (Active Gains in brain using Exercise During Aging) is a randomized controlled trial designed to examine the effects of a 24-week resistance exercise program on brain health in cognitively normal adults between 65-80 years of age.

Clinical Trial Description

Exercise has emerged as the most promising non-pharmacologic intervention for improving brain health in older adults. The main aim of AGUEDA (Active Gains in brain using Exercise During Aging) trial is to examine the effects of a 6-month resistance exercise program on executive function in cognitively normal older adults. The secondary aims are (i) to examine the effects of exercise on central and peripheral brain markers, and (ii) to investigate mediators and moderators of the exercise-derived improvements observed in executive function and brain markers. AGUEDA is a randomized controlled trial in which 88 cognitively normal older adults, aged 65-80 years old, will be randomized into an exercise group (n=44) or a wait-list control group (n=44). Participants assigned to the exercise group will participate in a 24-week resistance exercise program (3 sessions/week, 60 min/session), while the control group will be asked to maintain their usual lifestyle. A comprehensive neuropsychological test battery, amyloid PET scan, cutting-edge MRI scan, DXA scan, physical ļ¬tness, physical function and physical activity measures will be used. Blood, saliva and fecal samples will be collected. Mental health and psychosocial variables will be self-reported. ;

Study Design

Related Conditions & MeSH terms

NCT number NCT05186090
Study type Interventional
Source Universidad de Granada
Contact Irene Esteban-Cornejo, PhD
Phone 958220360
Email [email protected]
Status Recruiting
Phase N/A
Start date January 2, 2021
Completion date December 31, 2023

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