The Effect Of Anaerobic Exercise On Bone Morphogenetic Protein 9

Healthy Clinical Trial

Official title:

The Effect Of Anaerobic Exercise On Bone Morphogenetic Protein 9

Clinical Trial Details — Status: Active, not recruiting

Administrative data

• NCT number: NCT05117437
• Other study ID #: TDK-2020-22186
• Secondary ID: TDK-2020-22186
• Status: Active, not recruiting
• Start date: December 3, 2020
• Est. completion date: December 1, 2021

Study information

• Verified date: November 2021
• Source: Ege University
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

Bone morphogenetic protein (BMP) 9 from the BMP family has an important role in the remodeling of bone and cartilage. Due to these features, BMP9 can play an important role in especially anaerobic exercise training adaptations. However, the role of anaerobic exercise in these effects is still unclear. The aim of this study is to investigate the role of BMP9 on the effects of acute and chronic anaerobic exercise on bone metabolism markers. Postprandial venous blood samples were taken pre- and post- acute YOYO intermittent recovery test (level 1) in 40 trained male athletes aged 18-35 who did anaerobic sports (such as basketball, volleyball and handball) and 41 sedentary volunteers aged 18-35. Serum BMP9, as markers of bone formation and resorption; alkaline phosphatase (ALP), C-terminal telopeptide of type 1 collagen (CTX1), cartilage oligomeric matrix protein (COMP) and calcium levels were determined. The data to be obtained as a result of our study can give information about the relationship between the skeletal and bone health of the athletes and anaerobic exercise.

Recruitment information / eligibility

• Status: Active, not recruiting
• Enrollment: 81
• Est. completion date: December 1, 2021
• Est. primary completion date: June 1, 2021
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: Male
• Age group: 18 Years to 35 Years

Eligibility

Inclusion Criteria:

• being male

• having a body mass index of less than 30 being

Exclusion Criteria:

• to have some disease or disability

• to regularly use cigarettes and alcohol

• to use any medication or antioxidant substance

Related Conditions & MeSH terms

• Exercise
• Healthy

Intervention

Other:
• Physiological test
This test was conducted to determine the endurance levels of the participants.
• Physical test
Height, weight, and BMI were determined
• Biochemical tests
BMP9, CTX1, COMP, oxLDL protein levels, ALP, GGT, TAS, TOS, OSI, NO, calcium, T-C, LDL-C, Triglyceride, HDL-C, glucose, CRP, AST, ALT, erythrocyte, mean erythrocyte volume (MCV), hematocrit, leukocyte, thrombocyte levels were determined from blood samples.

Locations

Country	Name	City	State
Turkey	Ege University Faculty of Sport Sciences	Izmir

Sponsors (1)

Lead Sponsor	Collaborator
Ege University

Country where clinical trial is conducted

Turkey, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Change from serum BMP9 levels at pre- and post- YOYO intermittent test	Postprandial venous blood samples were obtained before and after acute YOYO IR test (level 1). The YOYO test lasted 10-20 minutes depending on the ability level of the participants. A blood sample was taken 15 minutes before and 15 minutes after the YOYO test. From these blood samples, serum Bone morphogenetic protein 9 (BMP9) was determined.	between 40-50 minutes
Primary	Change from serum CTX1 levels at pre- and post- YOYO intermittent test	Postprandial venous blood samples were obtained before and after acute YOYO IR test (level 1). The YOYO test lasted 10-20 minutes depending on the ability level of the participants. A blood sample was taken 15 minutes before and 15 minutes after the YOYO test. From these blood samples, serum C-terminal telopeptide of Type 1 collagen (CTX1) was determined.	between 40-50 minutes
Primary	Change from serum COMP levels at pre- and post- YOYO intermittent test	Postprandial venous blood samples were obtained before and after acute YOYO IR test (level 1). The YOYO test lasted 10-20 minutes depending on the ability level of the participants. A blood sample was taken 15 minutes before and 15 minutes after the YOYO test. From these blood samples, serum cartilage oligomeric matrix protein (COMP) was determined.	between 40-50 minutes