Healthy Clinical Trial
Official title:
The Effects of a Springtime Home Cleanse on Skin, Gut, Metabolic and Mental Health
This pilot study will evaluate the effects of a Springtime Home Cleanse on skin, gut, metabolic, and mental health. The study will also assess changes in overall quality of life. The results will be used to design a larger cleanse-based study in the future.
Status | Not yet recruiting |
Enrollment | 18 |
Est. completion date | April 3, 2022 |
Est. primary completion date | April 3, 2022 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | All |
Age group | 18 Years to 69 Years |
Eligibility | Inclusion Criteria: - Males and females (ages 18-69) - Individuals must be able to read and comprehend study procedures and consent forms. - Individuals who have baseline metabolic, gut or stress dysfunction - Individuals must be able to minimize activity during the home cleanse for full participation and compliance. - Individuals must be willing to reduce caffeine, sugar, alcohol, dairy and carbohydrate rich foods throughout the study. - Individuals must be willing to have flash photo facial images taken with imaging systems. Exclusion Criteria: - Individuals with a known allergy to lime or lime juice, ginger or ginger pickle, turbinado sugar, rock salt, curcumin, coriander, fennel, cardamom, cinnamon, trikatu, yellow mung dal, kitchari spice, triphala, dashamula and guduchi powder, castor oil and chyavanprash. - Individuals who are lactose intolerant, or with a known allergy to ghee. - Individuals who are in the process of being vaccinated. - Individual who have a history of gastrointestinal inflammatory diseases or a history or diagnosis of immunologic or infectious disease (e.g. hepatitis, tuberculosis, HIV or AIDS, lupus, rheumatoid arthritis) or other similar systemic diseases in the opinion of the investigator. - Individuals who are recovering from a serious illness (requiring hospitalization), infection (requiring hospitalization), or surgery within one month of starting the study or unwilling to wait one month after their illness, infection, or surgery prior to starting the study. - Individuals who are recovering from a non-serious illness or infection who are recovered and unwilling to wait 2 weeks from their illness or infection. - Individuals who are in a concurrent intervention based clinical research study at this site or any other facility in the past two weeks. - Has a condition or is on a medication the investigator and/or designee believes could jeopardize the safety of the subject, interfere with the evaluation, or confound the interpretation of the study results. - Individuals who have had exposure to systemic antibiotics within the month prior or unwilling to wash out for a month. - Women who are pregnant or breastfeeding. - Individuals who are cognitively impaired. - Prisoners |
Country | Name | City | State |
---|---|---|---|
United States | Integrative Skin Science and Research | Sacramento | California |
Lead Sponsor | Collaborator |
---|---|
Integrative Skin Science and Research | AyurPrana LLC, Pearl Banyan, LLC |
United States,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Microbiota diversity | Evaluation of gut microbiome diversity | 3 weeks | |
Primary | Microbiome intestinal markers | Zonulin, calprotectin, antibodies against LPS | 3 weeks | |
Secondary | Serum hemoglobin A1c (HbA1c) levels | Evaluate serum HbA1c level via ZRT Laboratories Cardiometabolic Panel | 3 weeks | |
Secondary | Serum high-sensitivity C-reactive protein (hsCRP) level | Evaluate serum hsCRP level via ZRT Laboratories Cardiometabolic Panel | 3 weeks | |
Secondary | Serum triglyceride (TG) level | Evaluate serum TG level via ZRT Laboratories Cardiometabolic Panel | 3 weeks | |
Secondary | Serum low density lipoprotein (LDL) level | Evaluate serum LDL level via ZRT Laboratories Cardiometabolic Panel | 3 weeks | |
Secondary | Serum high density lipoprotein (HDL) level | Evaluate serum HDL level via ZRT Laboratories Cardiometabolic Panel | 3 weeks | |
Secondary | Serum very low density lipoprotein (VLDL) level | Evaluate serum VLDL level via ZRT Laboratories Cardiometabolic Panel | 3 weeks | |
Secondary | Salivary diurnal cortisol pattern | Salivary diurnal cortisol pattern via ZRT Laboratories Saliva Hormone Test | 3 weeks | |
Secondary | Facial redness - image based | BTBP Clarity Mini 3D camera | 3 weeks | |
Secondary | Facial wrinkles - image based | BTBP Clarity Mini 3D camera | 3 weeks | |
Secondary | Facial trans-epidermal water loss (TEWL) | Vapometer, Delfin Technologies | 3 weeks | |
Secondary | Tongue changes - image based | Evaluate changes in tongue coating, discoloration, depressions, indentations, and cracking via iPad imaging | 3 weeks | |
Secondary | Quality of Life Survey Based Assessment | Self assessment using World Health Organization (WHO) Quality of Life Questionnaire | 3 weeks | |
Secondary | Safety assessments for GI distress | Self assessment using Digestive Questionnaire | 3 weeks | |
Secondary | Blood pressure | 3 weeks | ||
Secondary | Heart Rate | 3 weeks | ||
Secondary | Respiratory Rate | 3 weeks |
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