Healthy Clinical Trial
Official title:
Aerobic Interval and Moderate Continuous Exercise Training on Ventricular Functions
NCT number | NCT04815460 |
Other study ID # | 104-9615A3 |
Secondary ID | |
Status | Completed |
Phase | N/A |
First received | |
Last updated | |
Start date | July 1, 2016 |
Est. completion date | June 30, 2017 |
Verified date | March 2021 |
Source | Chang Gung Memorial Hospital |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Interventional |
Hypoxic exposure increases right ventricular (RV) afterload by triggering pulmonary hypertension, with consequent effects on the structure and function of the RV. Improved myocardial contractility is a critical circulatory adaptation to exercise training. However, the types of exercise that enhance right cardiac mechanics during hypoxic stress have not yet been identified. This study investigated how high-intensity interval training (HIIT) and moderate-intensity continuous training (MICT) influence right cardiac mechanics during hypoxic exercise (HE).
Status | Completed |
Enrollment | 54 |
Est. completion date | June 30, 2017 |
Est. primary completion date | June 30, 2017 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | Male |
Age group | 20 Years to 30 Years |
Eligibility | Inclusion Criteria: - Having a sedentary lifestyle (without regular exercise, exercise frequency = once weekly, duration < 20 min). Exclusion Criteria: - Exposed to high altitudes (> 3000 m) for at least 1 year. - Smoker - Taking medications or vitamins - Having any cardiopulmonary/hematological risk. |
Country | Name | City | State |
---|---|---|---|
Taiwan | Chang Gung University | Taoyuan |
Lead Sponsor | Collaborator |
---|---|
Chang Gung Memorial Hospital | Chang Gung University, National Science Council, Taiwan |
Taiwan,
Fu TC, Wang CH, Lin PS, Hsu CC, Cherng WJ, Huang SC, Liu MH, Chiang CL, Wang JS. Aerobic interval training improves oxygen uptake efficiency by enhancing cerebral and muscular hemodynamics in patients with heart failure. Int J Cardiol. 2013 Jul 15;167(1):41-50. doi: 10.1016/j.ijcard.2011.11.086. Epub 2011 Dec 22. — View Citation
Huang YC, Tsai HH, Fu TC, Hsu CC, Wang JS. High-Intensity Interval Training Improves Left Ventricular Contractile Function. Med Sci Sports Exerc. 2019 Jul;51(7):1420-1428. doi: 10.1249/MSS.0000000000001931. — View Citation
Jaijee S, Quinlan M, Tokarczuk P, Clemence M, Howard LSGE, Gibbs JSR, O'Regan DP. Exercise cardiac MRI unmasks right ventricular dysfunction in acute hypoxia and chronic pulmonary arterial hypertension. Am J Physiol Heart Circ Physiol. 2018 Oct 1;315(4):H950-H957. doi: 10.1152/ajpheart.00146.2018. Epub 2018 May 18. — View Citation
Naeije R, Badagliacca R. The overloaded right heart and ventricular interdependence. Cardiovasc Res. 2017 Oct 1;113(12):1474-1485. doi: 10.1093/cvr/cvx160. Review. — View Citation
Wang Z, Chesler NC. Pulmonary vascular mechanics: important contributors to the increased right ventricular afterload of pulmonary hypertension. Exp Physiol. 2013 Aug;98(8):1267-73. doi: 10.1113/expphysiol.2012.069096. Epub 2013 May 10. Review. — View Citation
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | The changes of right cardiac mechanics during hypoxia stress echocardiography: Strain | Hypoxia stress echocardiography was collected under hypoxic conditions (12% FiO2) and used two-dimensional Speckle-tracking echocardiography.
The resting images were acquired after the subject was placed in the aforementioned position for 10 min. The exercise images were conducted using semirecumbent cycling with a 50-Watt resistance for 3 min and acquired at the third minute of cycling to ensure that subjects had reached a steady-state HR (i.e., HR changes <10 bpm within 10 s and <110-120 bpm). A modified apical four-chamber view was used to assess 2D-STE longitudinal and radial parameters of the RV and RA. The RV strain was calculated using the average peak segmental values displayed by the software using a 6-segment model. |
8 weeks | |
Primary | The changes of right cardiac mechanics during hypoxia stress echocardiography: Strain rate | Hypoxia stress echocardiography was collected under hypoxic conditions (12% FiO2) and used two-dimensional Speckle-tracking echocardiography.
The resting images were acquired after the subject was placed in the aforementioned position for 10 min. The exercise images were conducted using semirecumbent cycling with a 50-Watt resistance for 3 min and acquired at the third minute of cycling to ensure that subjects had reached a steady-state HR (i.e., HR changes <10 bpm within 10 s and <110-120 bpm). A modified apical four-chamber view was used to assess 2D-STE longitudinal and radial parameters of the RV and RA. The RV strain rate was calculated using the average peak segmental values displayed by the software using a 6-segment model. |
8 weeks | |
Secondary | Cardiopulmonary fitness | To assess cardiopulmonary fitness, cardiopulmonary exercise test (CPET) on a cycle ergometer was performed 4 days before and after the intervention. All subjects underwent exercise with a mask to measured oxygen consumption (VO2) breath by breath using a computer-based system (Master Screen CPX, Cardinal-health Germany). | 8 weeks | |
Secondary | The cavity diameters of RV | RV basal cavity diameter (RVD1), mid-cavity diameter (RVD2), and RV longitudinal diameter (RVD3), at end-diastole and end-systole, were evaluated in the modified apical four-chamber view. | 8 weeks | |
Secondary | Pulmonary vascular resistance (PVR) | Pulmonary vascular resistance (PVR) was calculated using the formula PVR = ([tricuspid regurgitation velocity/RVOT VTI] × 10 + 0.16)
Tricuspid regurgitation velocity: Doppler imaging was used to measure peak tricuspid regurgitation velocities in systolic phase. The RV outflow tract (RVOT): obtained from a parasternal short-axis base view modified apical four-chamber view, and the flow immediately proximal to the pulmonary artery valve during systole was detected to calculate both maximal velocity and pulsed-wave blood velocity time integral (VTI) |
8 weeks | |
Secondary | RV diastolic function | Doppler imaging was used to measure peak tricuspid annular (E') and flow velocities (E) in early diastole. | 8 weeks | |
Secondary | Tricuspid annular plane systolic excursion (TAPSE) | Tricuspid annular plane systolic excursion (TAPSE) measures the longitudinal excursion of the tricuspid annulus in one dimension, which was measured by M-mode. | 8 weeks |
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