Healthy Clinical Trial - Comparison of Water Sorption Capacity &

Status Completed

Clinical Trial Summary

Pilot basic research study on the properties of bronchial mucus. Examination of the sorption and desorption properties, mucin concentration, and structure of the mucus from healthy airways compared to patients with Chronic Obstructive Pulmonary Disease (COPD).

Clinical Trial Description

Mucus, of the correct composition, maintains airway hydration and protects the airway from inhaled particles through mucociliary transport. In chronic inflammatory airway diseases such as COPD or cystic fibrosis, infectious agents, inflammatory cells and products of inflammation such as DNA, increase mucus viscosity which results in decreased mucociliary clearance of inhaled particles, increasing the likelihood of respiratory infections. This pilot study is planned as basic research on the properties of bronchial mucus. Water isotherms and efficient water activity (sorption and desorption) of the collected samples are examined in defined temperature and humidity settings using DVS Intrinsic (Dynamic Vapour Sorption System, Surface Measurement Systems, London, UK). Findings will provide insights into possible treatment programs targeted at altering specific mucus components. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT04703023
Study type	Observational
Source	Institut für Pneumologie Hagen Ambrock eV
Contact
Status	Completed
Phase
Start date	July 9, 2020
Completion date	May 17, 2023

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Comparison of Water Sorption Capacity and the Composition of Bronchial Fluids of Healthy Persons and Patients With Chronic Obstructive Bronchitis (COPD)

Clinical Trial Summary

Clinical Trial Description

Study Design

Related Conditions & MeSH terms