Trial Investigating the Characteristics of Knismesis - a Lever to Explore Allodynia in Neuropathic Pain

Healthy Clinical Trial

— TICKLE  

Official title:

Trial Investigating the Characteristics of Knismesis - a Lever to Explore Allodynia in Neuropathic Pain

Clinical Trial Details — Status: Recruiting

Administrative data

• NCT number: NCT04621747
• Other study ID #: RBHP 2020 DUALE
• Status: Recruiting
• Phase: N/A
• Start date: November 23, 2021
• Est. completion date: December 1, 2022

Study information

• Verified date: December 2021
• Source: University Hospital, Clermont-Ferrand
• Contact: Lise Laclautre
• Phone: 0473754963
• Email: promo_interne_drci[@]chu-clermontferrand.fr
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

Also known as a "moving itch", knismesis is a mildly annoying sensation caused by a light movement on the skin, such as from a crawling insect. Its underlying mechanism rely on spatial summation, i.e. amplification of the signal due to summation of stimulated fields, like it is for dynamic allodynia in neuropathic pain. This physiological study aims at determining the physical factors of the cutaneous stimulation inducing knismesis as well as the effect of confounding factors. The main area of exploration will be the back, because of its size and the possibility to blind the participant. The information collected, along with animal data in surrogate models, would help to better understand neuropathic pain in the future.

Description:

This is a physiological proof-of-concept, also aiming to validate a functional exploration model in healthy volunteers. Each participant will undergo a battery if psychometric then psychophysics tests, presented sequentially. However, most of the main study tests (knismesis) will be admistered in a random order (crossover). The primary endpoint is to characterise, in the healthy human, the physical determinants of the cutaneous stimulation inducing knismesis: length of the pathway, speed, direction, intensity, continuity break of the contact, hairiness, body site, or distraction by other cutaneous stimuli. The secondary endpoint is to study the relationship between the individual sensitivity to spatial summation (knismesis) and other individual sensitivities or profiles.

Recruitment information / eligibility

• Status: Recruiting
• Enrollment: 24
• Est. completion date: December 1, 2022
• Est. primary completion date: December 1, 2022
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 18 Years to 50 Years

Eligibility

Inclusion Criteria:

• Ability to answer French questionnaires.

· BMI between 19 and 30 kg/m2 at inclusion.

Exclusion Criteria:

• Pregnancy or breastfeeding.

• Natural intolerance to tickling.

• Any cutaneous, ocular or neurological disease contraindicating the psychophysical tests.

• Any disease or medical history that could expose the subject to unacceptable risk during the study.

• Any medication intake within 7 days before testing.

• History of drug or alcohol abuse.

• Involvement in another concomitant research protocol.

• Major dorsal hairiness.

• Inability to undergo the tests.

• Legal protection.

• Concomitant involvement in another clinical research.

• Refusal to participate.

Related Conditions & MeSH terms

• Healthy
• Hyperalgesia
• Neuralgia

Intervention

Other:
• Battery of neurophysiological explorations
Visit 1: Biometry collection: gender, age, weight, height, eye colour. Questionnaires : the State and Trait Anxiety Inventory and the Pain Sensitivity Threshold of unpleasant light brightness, mechanical sensitivity threshold (von Frey hair). Training to estimate unpleasantness Under nociceptive and tickling stimuli, to use the handgrip. Mechanical pain threshold (electronic von Frey), heat pain threshold (Medoc Pathway). 48 stimulations applied to the back skin, following a predetermined plan with 12 different pathways, imbricated with 4 different speeds of movement. Visit 2 (1 to 8 days later) : 42 stimulations applied to the back skin, to test the effect of stimulation intensity, the side of application, continuity break of the contact, and distraction by other cutaneous stimuli. The stimuli will follow the best paradigm as identified at the previous visit. 12 stimulations applied to forearm, cheeks, lower limbs, also testing the effect of hairiness.

Locations

Country	Name	City	State
France	University Hospital, Clermont Ferrand	Clermont-Ferrand	Auvergne

Sponsors (2)

Lead Sponsor	Collaborator
University Hospital, Clermont-Ferrand	NEURO-DOL (UMR 1107 INSERM / UCA)

Country where clinical trial is conducted

France, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Intensity of annoying sensation	After training, the annoying sensation is expressed by the subject through a handgrip dynamometer (Biopac systems). The signal will be treated and converted into area-under-curve response (Dualé C et al., Reg Anesth Pain Med 2011; 36:110-115).	Day 1
Primary	Intensity of annoying sensation	After training, the annoying sensation is expressed by the subject through a handgrip dynamometer (Biopac systems). The signal will be treated and converted into area-under-curve response (Dualé C et al., Reg Anesth Pain Med 2011; 36:110-115).	Day 8
Secondary	Muscular aversive response.	The muscular aversive response will be assessed by surface electromyography through paraspinal contact electrodes (Biopac systems).	Day 1, Day 8