Lung Diffusing Capacity for Nitric Oxide During Cycling Exercise

Healthy Clinical Trial

Official title:

Test-retest Reliability of Lung Diffusing Capacity for Nitric Oxide During Light and Moderate Intensity Cycling Exercise

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT04618302
• Other study ID #: 2020-01756
• Status: Completed
• Start date: October 19, 2020
• Est. completion date: January 1, 2021

Study information

• Verified date: April 2021
• Source: University of Zurich
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

This study investigates the test-retest reliability of the lung diffusing capacity for nitric oxide in healthy individuals during exercise.

Description:

The aim of this study of to evaluate the test-retest reliability of single-breath lung diffusing capacity measurements for nitric oxide (DLNO) in healthy individuals during light and moderate intensity cycling exercise. Healthy subjects will perform repeated single-breath DLNO measurements during light (i.e., at 50% of the first ventilatory threshold) and moderate intensity exercise (i.e., 80% of the first ventilatory threshold) on a stationary cycle ergometer.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 17
• Est. completion date: January 1, 2021
• Est. primary completion date: December 31, 2020
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 18 Years and older

Eligibility

Inclusion Criteria:

• Healthy

• Age 18 yrs and older

• Ability to follow study procedures and instructions in German

Exclusion Criteria:

• Any known cardiopulmonary or metabolic diseases (e.g., heart disease, diabetes mellitus etc)

• Obesity (BMI > 30kg/m2)

• Smoking (ex-smoker allowed; if they stopped smoking at least one year before the examination)

• Mental impairment leading to inability to cooperate

• Respiratory infection in the last two weeks

• Forced expiratory volume in 1s/ forced vital capacity (FEV1/FVC ratio) FEV1/FVC ratio < lower limit of normal according to equations by Quanjer et al. Eur Respir J 2012.

Related Conditions & MeSH terms

• Healthy

Locations

Country	Name	City	State
Switzerland	University of Zurich and University Hospital of Zurich	Zurich

Sponsors (1)

Lead Sponsor	Collaborator
Thomas Radtke

Country where clinical trial is conducted

Switzerland, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Diffusing capacity for nitric oxide (DLNO)	DLNO (in ml/min/mmHg) measured at 80% of the gas exchange threshold during cycling exercise.	At second study visit
Primary	Diffusing capacity for nitric oxide (DLNO)	DLNO (in ml/min/mmHg) measured at 80% of the gas exchange threshold during cycling exercise.	At third study visit, approximately 1-2 weeks after second study visit
Secondary	Diffusing capacity for nitric oxide (DLNO)	DLNO (in ml/min/mmHg) measured at 50% of the gas exchange threshold during cycling exercise.	At second study visit
Secondary	Diffusing capacity for nitric oxide (DLNO)	DLNO (in ml/min/mmHg) measured at 50% of the gas exchange threshold during cycling exercise.	At third study visit, approximately 1-2 weeks after second study visit
Secondary	Diffusing capacity for carbon monoxide (DLCO)	DLCO (in ml/min/mmHg) measured at 50% of the gas exchange threshold during cycling exercise.	At second study visit
Secondary	Diffusing capacity for carbon monoxide (DLCO)	DLCO (in ml/min/mmHg) measured at 50% of the gas exchange threshold during cycling exercise.	At third study visit, approximately 1-2 weeks after second study visit
Secondary	Diffusing capacity for carbon monoxide (DLCO)	Agreement in DLCO (in ml/min/mmHg) measured at 80% of the gas exchange threshold during cycling exercise.	At second study visit
Secondary	Diffusing capacity for carbon monoxide (DLCO)	Agreement in DLCO (in ml/min/mmHg) measured at 80% of the gas exchange threshold during cycling exercise.	At third study visit, approximately 1-2 weeks after second study visit
Secondary	Alveolar volume (VA)	VA (in L) measured at 50% of the gas exchange threshold during cycling exercise.	At second study visit
Secondary	Alveolar volume (VA)	VA (in L) measured at 50% of the gas exchange threshold during cycling exercise.	At third study visit, approximately 1-2 weeks after second study visit
Secondary	Alveolar volume (VA)	Alveolar volume (in L) measured at 80% of the gas exchange threshold during cycling exercise.	At second study visit
Secondary	Alveolar volume (VA)	Alveolar volume (in L) measured at 80% of the gas exchange threshold during cycling exercise.	At third study visit, approximately 1-2 weeks after second study visit
Secondary	Breath hold time (BHT)	BHT (in s) measured at 80% of the gas exchange threshold during cycling exercise.	At second study visit
Secondary	Breath hold time (BHT)	BHT (in s) measured at 80% of the gas exchange threshold during cycling exercise.	At third study visit, approximately 1-2 weeks after second study visit
Secondary	Breath hold time (BHT)	BHT (in s) measured at 50% of the gas exchange threshold during cycling exercise.	At second study visit
Secondary	Breath hold time (BHT)	BHT (in s) measured at 50% of the gas exchange threshold during cycling exercise.	At third study visit, approximately 1-2 weeks after second study visit