Pre-workout Supplement Versus Caffeine on Energy Expenditure.

Healthy Clinical Trial

Official title:

Effects of a Multi-ingredient Pre-workout Supplement Versus Caffeine on Energy Expenditure and Feelings of Fatigue During Low-intensity Treadmill Exercise in College-aged Males.

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT04539054
• Other study ID #: HS19-0163
• Status: Completed
• Phase: N/A
• Start date: September 1, 2019
• Est. completion date: December 31, 2019

Study information

• Verified date: August 2020
• Source: Northern Illinois University
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

The primary purpose of this study was to examine the acute effects of a multi-ingredient pre-workout supplement versus an ergogenic dose of caffeine (6 mg/kg) on energy expenditure during low-intensity exercise. The effects of these substances on substrate utilization, gas exchange, and psychological factors were also investigated. Twelve males (mean ± SD: age = 22.8 ± 2.4 years) completed three bouts of 60-min of treadmill exercise at 4.8-6.4 km/hr on separate days after consuming a pre-workout supplement, 6 mg/kg of caffeine, or placebo in a randomized fashion. The pre-workout and caffeine supplements resulted in significantly greater energy expenditure (p < 0.001, p = 0.006, respectively), VO2 (p < 0.001, p = 0.007, respectively), VCO2 (p = 0.006, p = 0.049, respectively), and VE (p < 0.001, p = 0.007, respectively), but not rates of fat or carbohydrate oxidation or respiratory exchange ratio compared to placebo (collapsed across condition). In addition, the pre-workout supplement increased feelings of alertness (p = 0.015) and focus (p = 0.005) 30-minutes post-ingestion and decreased feelings of fatigue (p = 0.014) during exercise compared to placebo (collapsed across condition). Thus, the pre-workout supplement increased energy expenditure and measures of gas exchange to the same extent as 6 mg/kg of caffeine with concomitant increased feelings of alertness and focus and decreased feelings of fatigue.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 12
• Est. completion date: December 31, 2019
• Est. primary completion date: December 31, 2019
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: Male
• Age group: 19 Years to 29 Years

Eligibility

Inclusion Criteria:

• Male

Exclusion Criteria:

• history of medical or surgical events, including cardiovascular disease, metabolic, renal, hepatic, or musculoskeletal disorders;

• use of any medications

• use of nutritional supplements

• habitual use of caffeine (=1 caffeinated beverage per day)

• participation in another clinical trial or investigation of another investigational product within 30 days prior to screening/enrollment.

Related Conditions & MeSH terms

• Healthy

Intervention

Dietary Supplement:
• ENGN Shred
ENGN Shred is a multi-ingredient pre-workout supplement.
• Nutricost caffeine powder
Caffeine powder.
• Crystal Light
Non-caloric Crystal Light matched for the pre-workout in terms of flavor and consistency.

Locations

Country	Name	City	State
United States	Exercise Physiology Laboratory	DeKalb	Illinois

Sponsors (1)

Lead Sponsor	Collaborator
Northern Illinois University

Country where clinical trial is conducted

United States, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Energy expenditure	Measurement of caloric expenditure via gas exchange	Measured continuously during 60 minutes of exercise for all three supplement conditions
Secondary	Oxygen consumption	Measurement of rate of oxygen consumption using a metabolic cart	Measured continuously during 60 minutes of exercise for all three supplement conditions
Secondary	Carbon dioxide production	Measurement of rate of carbon dioxide production using a metabolic cart	Measured continuously during 60 minutes of exercise for all three supplement conditions
Secondary	Minute ventilation	Measurement of ventilation rate using a metabolic cart	Measured continuously during 60 minutes of exercise for all three supplement conditions
Secondary	Feelings of fatigue	Subjects were asked to rate their feelings of fatigue using a 5-point Likert scale	Baseline, 30-minutes post-ingestion of supplement, and at the 30-minute time point of exercise for all three supplement conditions
Secondary	Feelings of energy	Subjects were asked to rate their feelings of energy using a 5-point Likert scale	Baseline, 30-minutes post-ingestion of supplement, and at the 30-minute time point of exercise for all three supplement conditions
Secondary	Feelings of focus	Subjects were asked to rate their feelings of focus using a 5-point Likert scale	Baseline, 30-minutes post-ingestion of supplement, and at the 30-minute time point of exercise for all three supplement conditions
Secondary	Feelings of alertness	Subjects were asked to rate their feelings of focus using a 5-point Likert scale	Baseline, 30-minutes post-ingestion of supplement, and at the 30-minute time point of exercise for all three supplement conditions
Secondary	Rate of fat oxidation	Fat oxidation was estimated thru measurements of gas exchange	Measured continuously during 60 minutes of exercise for all three supplement conditions
Secondary	Rate of carbohydrate oxidation	Carbohydrate oxidation was estimated thru measurements of gas exchange	Measured continuously during 60 minutes of exercise for all three supplement conditions