Healthy Clinical Trial
Official title:
Optimizing Platelet Isolation for Measures of Human Platelet Mitochondrial Respiration (The Cell Study)
Verified date | December 2023 |
Source | Arkansas Children's Hospital Research Institute |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Observational |
The research study is about blood cells (platelets) and their power houses (mitochondria). The investigators want to learn about their behavior in order to ensure that our laboratory procedures are generating optimal results.
Status | Active, not recruiting |
Enrollment | 20 |
Est. completion date | December 20, 2024 |
Est. primary completion date | September 1, 2023 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | All |
Age group | 25 Years to 35 Years |
Eligibility | Inclusion Criteria: - Age 25-35 - All races - All ethnicity - 18.5 - 30 BMI Exclusion Criteria: - smoking - Aspirin intake - Recreational drug use - Alcohol intake more than 3 times per week - Self-reported possibility of current pregnancy - Known diagnosis of: - Pre-diabetes - Diabetes - High cholesterol - High triglycerides - Hypertension - Anemia - Autism spectrum disorder - Attention deficit hyperactivity disorder (ADHD) - Attention deficit disorder (ADD) - Severe asthma - Refusal to stop taking nutritional supplements - Any other pre-existing medical condition that requires daily medication as determined by the investigators to affect outcome of interest |
Country | Name | City | State |
---|---|---|---|
United States | Arkansas Children's Nutrition Center | Little Rock | Arkansas |
Lead Sponsor | Collaborator |
---|---|
Arkansas Children's Hospital Research Institute |
United States,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Platelet activation from isolated platelets | Whole blood will be collected following an overnight fast, and platelets isolated using standard procedures. Platelet activation markers (e.g., CD62P ) will be measured using flow cytometric analysis. | day 1 | |
Secondary | Platelet activation measured in whole blood | Whole blood will be collected following an overnight fast. Platelet activation will be measured in whole blood by the expression CD62P | day 1 | |
Secondary | Platelet reactivity measured in whole blood | Whole blood will be collected following an overnight fast. Platelet reactivity will be measured in whole blood with adenosine diphosphate (ADP). | day 1 |
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