The Relationship Between Maximal Oxygen Consumption and Inspiratory Muscle Activation Pattern Under Loaded Inspiratory Muscle Tests in Healthy Adults

Healthy Clinical Trial

Official title:

The Relationship Between Maximal Oxygen Consumption and Inspiratory Muscle Activation Pattern Under Loaded Inspiratory Muscle Tests in Healthy Adults

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT04463732
• Other study ID #: 202005050RINA
• Status: Completed
• Start date: July 1, 2020
• Est. completion date: December 31, 2020

Study information

• Verified date: June 2020
• Source: National Taiwan University Hospital
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

Maximal oxygen consumption, VO2max, is the gold standard to evaluate human aerobic fitness, which stands for the maximal capacity of cardiorespiratory system and musculoskeletal system to transport and utilize oxygen. Previous study showed that there is significant correlation between maximal oxygen consumption from cardiopulmonary exercise test and strength and endurance of lower extremities. In people with sedentary lifestyle, they often limited by the lower limb muscle performance during cardiopulmonary exercise test. Their breathing patterns are more irregular than athletes during cardiopulmonary exercise test. However, there is no study comparing the activation pattern of respiratory muscles between these two groups. Whether the breathing pattern in people with lower exercise capacity is less efficient under exertional activities still unknown. The purpose of this study is to investigate the relationship between maximal oxygen consumption and inspiratory muscle activation pattern in healthy adults.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 10
• Est. completion date: December 31, 2020
• Est. primary completion date: December 31, 2020
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 20 Years and older

Eligibility

Inclusion Criteria:

• Healthy adults (age > 20 years old)

• Be able to cooperate with the measurements of this study

Exclusion Criteria:

• any clinical diagnosis that will influence the measurement, including any history of neuromyopathy

• angina, acute myocardial infarction in the previous one month

• pregnancy

• history of syncope during exercise

• any musculoskeletal system disorder that unable to perform cardiopulmonary exercise test

Related Conditions & MeSH terms

• Healthy
• Respiratory Aspiration

Intervention

Other:
• Loaded inspiratory muscle test and cardiopulmonary exercise test
This is an observational study. Loaded inspiratory muscle test is setting at 30% of maximal inspiratory pressure. Subjects will perform only 15 breaths under this intensity to exam the performance of their inspiratory muscles. Loaded inspiratory muscle test is not for training. Cardiopulmonary exercise test is performed by using bicycle ergometer. These two tests will be performed at least 1 week separately.

Locations

Country	Name	City	State
Taiwan	School and Graduate Institute of Physical Therapy of National Taiwan University	Taipei	Zhongzheng Dist

Sponsors (1)

Lead Sponsor	Collaborator
National Taiwan University Hospital

Country where clinical trial is conducted

Taiwan, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Diaphragm and Sternocleidomastoid muscle activation	Root mean square values	during the loaded inspiratory muscle test condition; it would take about 3 minutes
Primary	Maximal exercise capacity	Maximal oxygen consumption	during the cardiopulmonary exercise test; it would take about 12 to 15 minutes