Effects of a Multi-Ingredient Pre-Workout Supplement on Energy Expenditure During Running

Healthy Clinical Trial

Official title:

Effects of One Versus Two Doses of a Multi-Ingredient Pre-Workout Supplement on Metabolic Factors and Perceived Exertion During Moderate-Intensity Running in Females

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT04352998
• Other study ID #: NorthernIU
• Status: Completed
• Phase: N/A
• Start date: May 16, 2016
• Est. completion date: May 16, 2016

Study information

• Verified date: April 2020
• Source: Northern Illinois University
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

The primary purpose of this study was to examine the acute effects of one versus two doses of a multi-ingredient pre-workout supplement on energy expenditure during moderate-intensity treadmill running. In addition, our second aim was to investigate the responses of associated metabolic factors (i.e. substrate utilization, measures of gas exchange), perceived exertion, and resting cardiovascular variables with one and two doses of the pre-workout supplement.

Description:

This study utilized a randomized, double-blind, placebo-controlled, within-subjects crossover design (Figure 1). Each subject was required to visit the laboratory on five occasions with 72-96 hours between sessions. During the first laboratory visit, each subject performed an incremental test on a treadmill to familiarize the subjects with the testing procedures. For the second laboratory visit, each subject performed an incremental treadmill test to exhaustion to determine their ventilatory threshold (VT). The third laboratory visit was completed in the morning (06:00-09:00) and required subjects to consume a standardized meal after fasting overnight (8 hours) and sat quietly for 30 minutes before baseline heart rate and blood pressure values were recorded. The subjects were then randomly assigned to ingest the supplement (one or two doses) or placebo and sit quietly for another 30 minutes. The ingredients of the supplement (Cellucor, Bryan, TX) are provided in Table 1. The placebo was non-energetic and controlled for similar appearance and taste. At the 15-minute and 30-minute post-ingestion periods (of the pre-workout supplement or placebo), resting heart rate and blood pressure were recorded for a second and third time, respectively. Subjects then performed a 30-minute constant-velocity treadmill run at 90% of their VT. The subjects then returned to the laboratory for their fourth and fifth visits to ingest the remaining substances (1-dose, 2-dose, or placebo) and undergo the same testing procedures (including time of day) as the third visit. Each subject recorded 2-day food logs (MyFitnessPal, Inc., USA) prior to each laboratory visit.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 12
• Est. completion date: May 16, 2016
• Est. primary completion date: May 16, 2016
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: Female
• Age group: 19 Years to 29 Years

Eligibility

Inclusion Criteria:

• ran = 16 km per week

Exclusion Criteria:

• (i) history of medical or surgical events, including cardiovascular disease, metabolic, renal, hepatic, or musculoskeletal disorders; (ii) use of any medication; (iii) use of nutritional supplements; (iv) habitual use of caffeine (= one cup of coffee or caffeinated beverage per day); or (v) participation in another clinical trial or investigation of another investigational product within 30 days prior to screening/enrollment.

Related Conditions & MeSH terms

• Healthy

Intervention

Dietary Supplement:
• One dose pre-workout condition
one dose of a multi-ingredient pre-workout supplement
• Two dose pre-workout condition
two doses of a multi-ingredient pre-workout supplement
• Placebo condition
one dose of a placebo

Locations

Country	Name	City	State
n/a

Sponsors (4)

Lead Sponsor	Collaborator
Northern Illinois University	Mayo Clinic, Nova Southeastern University, University of Wisconsin, La Crosse

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Energy expenditure	energy expenditure measured as kcals per minute	30 minutes of exercise
Secondary	substrate utilization	fat and carbohydrate oxidation	30 minutes of exercise
Secondary	measures of gas exchange	oxygen consumption, respiratory exchange ratio	30 minutes of exercise
Secondary	perceived exertion	ratings of perceived exertion (RPE)	30 minutes of exercise
Secondary	resting cardiovascular variables	heart rate, systolic and diastolic blood pressure	baseline and 30 minutes post-ingestion