Healthy Clinical Trial
Official title:
High Resolution Colonic Manometry in Relation to 3D-Transit Times in Healthy Controls.
Background: Within recent years, new methods for detailed assessment of gastrointestinal (GI)
motility have been developed. Hence, the electromagnetic 3D-Transit system is a safe,
non-invasive method for detailed description of GI motility. The system tracks the exact
position of an ingested electromagnetic capsule through the entire GI tract and provides
detailed information on both regional transit- and contraction patterns. High Resolution
Colonic Manometry (HRCM) allows extremely detailed description of contraction patterns in the
colon. The HRCM is however an invasive method, as the catheter is placed during colonoscopy.
Before widespread use of capsule-based techniques (3D-Transit or others), the system needs to
be validated by another method.
Study Objectives: The purpose of this study is to investigate weather pressure changes
measured by HRCM correlate with passage patterns recorded by 3D-Transit. This has been
assumed so far, but has never been further investigated.
Hypothesis: Movement of the electromagnetic 3D-Transit capsule within the colon correspond
well with pressure changes determined with HRCM.
Materials and methods: HRCM and 3D-transit will be performed simultaneously in 20 healthy
participants. A colonoscopy is performed to install the HRCM catheter and place two
3D-Transit capsules within the colon. For 24 hours, the participants lie in a bed in the
research lab while pressure changes from the HRCM catheter are recorded and the 3D-Transit
capsules are followed through the gastrointestinal system.
Perspectives: If data from the 3D-Transit technique correlate well with HRCM, the method
provide a non-invasive alternative allowing detailed assessment of colonic motility.
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