Healthy Clinical Trial
Official title:
Characterization of Gingival Crevicular Fluid During Orthodontic Tooth Movement
NCT number | NCT04226469 |
Other study ID # | 2013-0183 |
Secondary ID | |
Status | Recruiting |
Phase | |
First received | |
Last updated | |
Start date | January 1, 2019 |
Est. completion date | June 30, 2020 |
During Orthodontic tooth movement, teeth are moved through alveolar bone under applied
forces. The applied mechanical loading force must be transferred to the alveolar bone via
periodontal ligament (PDL). This process of mechanotransduction stimulates bone remodeling
during which osteoblasts produce bone on the tension side and osteoclasts resorb bone on the
compression side of the PDL. Complex interactions between osteoblasts and osteoclasts involve
numerous biologic molecules including cytokines and growth factors. During the tooth
movement, the expression of cytokines such as interleukin (IL)-1β, IL-6, IL-8, prostaglandin
E2, RANKL and MMP1 in PDL will be up-regulated. The sequence of events from the
mechanotransduction commanding the tightly controlled accomplishment of osteogenesis
attention sides and osteoclastogenesis at compressive sides is not completely understood.
The gingival crevicular fluid (GCF) is a transudate of interstitial tissues that is produced
by an osmotic gradient and it is released into the crevicular crevices at a flow rate of
about 3 ul/h. Orthodontic treatment is triggered by an inflammatory process and it has been
hypothesized that the quantification of specific biomarkers within the GCF can be determined
using Periotron. However contrasting results have been reported in the literature, which
studies showing both increased or unchanged GCF volumes incident to orthodontic treatment.
Given that the orthodontic treatment is triggered by a set of inflammatory cytokines that are
released into the crevicular fluid during the mechanical loading, and its homeostasis is
dependent on mechanical stimulation. An understanding of the biological response of
crevicular fluid to mechanical loading could further advance the knowledge of orthodontic
treatment.
In this study, the investigators will investigate the biological response of gingival
crevicular fluid before and after the initial wire placement of orthodontic treatment to
determine the differentially expressed genes and proteins related to mechanotransduction.
Status | Recruiting |
Enrollment | 100 |
Est. completion date | June 30, 2020 |
Est. primary completion date | June 30, 2020 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | All |
Age group | 11 Years to 35 Years |
Eligibility |
Inclusion Criteria: - Healthy, non-smoking patients aged 11-35 years old who require orthodontic treatment with the first premolar extraction at the orthodontic clinic at College of Dentistry, the University of Illinois at Chicago (UIC) Exclusion Criteria: - Craniofacial syndromic subjects - periodontal pathology - systemic problems and underlying diseases - smoking |
Country | Name | City | State |
---|---|---|---|
United States | Department of Orthodontics, Clinic | Chicago | Illinois |
Lead Sponsor | Collaborator |
---|---|
University of Illinois at Chicago |
United States,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | The distance of tooth movement | The distance of tooth movement from initial timepoint to the end of study | 7 weeks | |
Primary | The fold change of secretory microRNA expression | The fold change of secretory microRNA expression compared to the initial level | 7 weeks | |
Primary | The amount of crevicular fluid | the volume of crevicular fluid | 7 weeks |
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