Healthy Clinical Trial
Official title:
Tissue Sodium Accumulation in Patients With Psoriasis: a Pilot Study
Sodium can be buffered in the skin, which mechanism is altered during aging and in certain diseases such as hypertension. High salt environment can promote autoimmunity by expanding pathogenic IL-17 producing T helper (Th17) cells. Psoriasis is a relapsing and remitting inflammatory autoimmune disease affecting the skin and joints and involves proinflammatory Th17 cells. Here we tested the hypothesis if psoriatic skin has a higher sodium content in humans.
The cytokine interleukin-17A (IL-17A) is a crucial player in the pathogenesis of the
autoimmune disease of psoriasis. This neutrophil recruiting cytokine is produced by IL-17A
producing CD4+ T cells (Th17) and gamma/delta T cells of the skin and evokes an inflammation
circuit finally leading to the classical clinical picture of psoriasis with hyper- and
parakeratosis, erythema, scaling and neutrophil abscess formation.
Besides genetic factors, lifestyle factors are relevant and decide if an autoimmune disease
becomes manifest. It was shown previously that increased salt (sodium chloride, NaCl)
concentrations boost the induction of murine and human Th17 cells. However, more - and also
clinical - studies are needed to understand the correlation between salt content and IL-17A
in autoimmune diseases.
This study investigates the hypothesis if skin sodium content in human psoriasis is increased
in order to get further insight into the IL-17A-salt-interplay.
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