Investigation of Fat Oxidation During Moderate Versus Vigorous Intensity Exercise

Healthy Clinical Trial

— FATOX  

Official title:

Investigation of Fat and Carbohydrate Oxidation During Moderate Versus Vigorous Intensity Exercise in Healthy Volunteers With Sedentary Lifestyle

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT03864679
• Other study ID #: Exercise 2018-1
• Status: Completed
• Phase: N/A
• Start date: June 18, 2018
• Est. completion date: August 30, 2018

Study information

• Verified date: March 2019
• Source: Latvian Institute of Organic Synthesis
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

Exercise is widely suggested as an important lifestyle change for weight loss, however, the optimal level of intensity moderate versus vigorous remains unclear. It is known that in athletes, during very high-intensity exercise, fat oxidation is decreased and energy is gained mainly from carbohydrate utilization. The aim of this study is to find an optimal workload based on fat oxidation rate during exercise in volunteers with a sedentary lifestyle.

Description:

It is planned to recruit 12 healthy volunteers with a sedentary lifestyle in the study group. Since different regimens (fed, fasted and moderate versus vigorous) will be compared in the same subjects, no control group is necessary. Subjects will perform a cycling test with 5 min incremental intensity exercise and 1 h cycling test exercising at a moderate-intensity (load will be selected after the incremental intensity exercise). The expiration of carbon dioxide (CO2) and consumption of oxygen (O2) will be measured, to determine the total fatty acid and carbohydrate oxidation during cycling. Concomitantly, it is planned to measure blood lactate and glucose concentrations during exercise experiments as well as a wide range of blood biochemistry parameters before and after exercise.

The investigators expect to find optimal conditions for the sedentary population for burning of fat, which is the major source of energy during moderate-intensity exercise. Measurements of the fat and carbohydrate oxidation in healthy volunteers with a sedentary lifestyle will contribute to the understanding of exercise regimens for the most effective fat oxidation.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 12
• Est. completion date: August 30, 2018
• Est. primary completion date: August 15, 2018
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 20 Years to 55 Years

Eligibility

Inclusion Criteria:

• Healthy

• Sedentary lifestyle

• BMI 20 - 30 kg/m2

• Be able to attend the laboratory and willing to participate in necessary protocols

• Be willing to undertake the duration of the exercise protocol (3 x 1 hour)

• Have the capacity and willingness to provide informed consent (oral and written)

Exclusion Criteria:

• athletes

• Individuals with chronic cardiovascular disease such as hypertension, valve disease, coronary artery disease, cardiac conduction abnormalities, etc.

• History of pneumothorax or chronic lung disease such as asthma, COPD, bronchiectasis

• Active Smokers

• Pregnant women

Related Conditions & MeSH terms

• Healthy
• Sedentary Lifestyle

Intervention

Other:
• Exercise
Subjects will perform a cycling test with 5 min incremental intensity exercise and 1 h cycling test exercising at a moderate-intensity (load will be selected in incremental intensity exercise).

Locations

Country	Name	City	State
Latvia	Latvian University	Riga

Sponsors (4)

Lead Sponsor	Collaborator
Latvian Institute of Organic Synthesis	Riga East University Hospital, Riga Stradins University, University of Latvia

Country where clinical trial is conducted

Latvia, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Optimal workload	The exercise workload (W) for optimal fat burning during exercise	30 min accelerated load cycling exercise
Primary	Heart rate change	Change in heart rate (BPM) from rest to the optimal workload	30 min accelerated load cycling exercise and 60 min optimal intensity cycling exercise
Secondary	Influence of fed and fasted state	The influence of fed and fasted state on maximal whole body fat oxidation rate during exercise	30 min accelerated load cycling exercise