Healthy Clinical Trial
Official title:
Acute Effect of a Standardized Botanical Blend Rich in Polyphenols on Cognitive Functions in Healthy Students: Randomized, Placebo-controlled, Double-blind, Cross-over Clinical Trial
Available literature suggests that flavanols-rich foods, and more especially monomeric
flavanols-rich foods such as grape, can have an acute effect on cognitive functions via
different mechanisms such as cerebral blood flow improvement.
The objective of this study is to investigate the effect of a Standardized botanical blend
rich in polyphenols (SBRP), on cognitive functions, together with endothelial function in
healthy students. Moreover, in order to provide supportive evidence on the mechanisms and
biological plausibility to the clinical effects of the product, appropriate biological
parameters and circulating metabolites will be assayed.
The study design will be a double-blind, randomised, placebo controlled, crossover study. A
total of 30 healthy volunteers will be included. Each participant will receive a single dose
of SBRP and placebo capsules, during 2 separate experimental visits and in a counterbalanced
order. There will be a 1 week washout period between the 2 experimental visits. During each
experimental visit, after a training battery volunteers will be administered a cognitive test
battery (COMPASS) before product intake and 6 times after product intake (B1 to B6, from 90
min post-dose to 160 min post-dose).
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