Healthy Clinical Trial
Official title:
Computational Drug Repurposing for All Epidermolysis Bullosa Simplex (EBS) Cases
NCT number | NCT03269474 |
Other study ID # | 41142 |
Secondary ID | |
Status | Recruiting |
Phase | |
First received | |
Last updated | |
Start date | November 28, 2017 |
Est. completion date | December 31, 2024 |
The study will compare gene expression differences between blistered and non-blistered skin from individuals with all subtypes of EB, as well as normal skin from non-EB subjects. State of the art computational analysis will be performed to help identify new drugs that might help all EB wound healing and reduce pain. Researchers will focus on drugs that have already been approved for treatment of other dermatologic or non-dermatologic diseases, and therefore be repurposed for treatment of EB. Drug development is a very expensive process taking decades for execution. Drug repurposing on the other hand, significantly reduces the cost and shortens the amount of time that is needed to bring effective treatments to clinical use. To date, there is no specific treatment targeting the physiology and immunologic response in EB patients during wound healing. Market availability of repurposed medications will provide all EB patients rapid access to treatments, thus improving their quality of life.
Status | Recruiting |
Enrollment | 60 |
Est. completion date | December 31, 2024 |
Est. primary completion date | December 30, 2024 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | All |
Age group | 0 Years and older |
Eligibility | Inclusion Criteria: - Subjects of all ages - Diagnosis of all subtypes of EB subjects - Healthy, non-EB subjects - Ability to complete study visit to collect tissue and blood specimen Exclusion Criteria: - Pregnancy, breast feeding - Prior history of liver disease - Serious known concurrent medical illness or infection, which could potentially present a safety risk and/or prevent tissue collection from subjects |
Country | Name | City | State |
---|---|---|---|
United States | Pediatric Dermatology Clinic at Stanford Children's Hospital | Palo Alto | California |
Lead Sponsor | Collaborator |
---|---|
Joyce Teng |
United States,
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* Note: There are 17 references in all — Click here to view all references
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Characterize gene expression changes in EB using RNA sequencing (RNA-seq) and Computational Profiling Potential Drug Targets | Using bioinformatic algorithms to identify changes in gene expression and review of over 2000 FDA-approved drugs based on predicted modulation of gene expression changes using a computational evolutionary algorithm system. | Through the completion of study in 1 year. |
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