SLeep and IMagery Correlates (SOMMEIL-IMAGERIE)

Healthy Clinical Trial

Official title:

Neurophysiological Correlates of Sleep Motor Consolidation Following Motor Imagery Practice

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT03130322
• Other study ID #: 69HCL16_0676
• Status: Completed
• Phase: N/A
• Start date: December 9, 2015
• Est. completion date: July 4, 2018

Study information

• Verified date: June 2021
• Source: Hospices Civils de Lyon
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

This study is designed to determine the neural networks underlying the sleep-related motor consolidation process following motor imagery practice. While beneficial effects of sleep are expected for sequential movement but not for adaptation motor tasks, the corresponding neuroanatomical correlates have not yet been investigated when participants acquired the motor tasks through mental practice. Data should substantially promote how designing motor imagery interventions targeting (re)learning and/or motor recovery in patients suffering from motor disorders.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 51
• Est. completion date: July 4, 2018
• Est. primary completion date: December 9, 2017
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 18 Years to 40 Years

Eligibility

Inclusion Criteria:

• Healthy right-handed persons without neurologic disease

• Persons having signed informed consent for a neuroimagery study

Exclusion Criteria:

• Persons under curatorship or any administrative/judicial measure

• Participants refusing to be informed of the results of the experiment

• Pregnant women

• Participants with contraindications to the MEG examination: head size, presence of a neurostimulator, steel pivot for the root canal, metallic fragments, ear implants, metal screws in the body or mouth.

• Persons using a pacemaker, insulin pump, or working regularly with iron filings

• Claustrophobic persons

Related Conditions & MeSH terms

• Healthy

Intervention

Other:
• Imagery and Sleep questionnaires
Participants complete a motor imagery questionnaire to assess their ability to form vivid mental images, as well as sleep questionnaires to control the quality of their sleep
• MEG recordings (pre-test)
Participants of the Day group perform two motor tasks (a finger sequential motor task and an adaptation motor task using a trackball) in the MEG, during a pre-test (Day 1 - 9h). Task 1: Participants perform an 8-digit motor sequential task where each finger (except the thumb) is used twice. Performance is assessed by using a 4-keys keyboard. Participants are required to keep their fingers on the keys to minimize amplitude are instructed to tap the sequence as few errors as possible Task 2: Participants perform a motor adaptation task requiring scrolling a trackball to superimpose a geometric shape on another one, strictly similar but presented from another angle, as fast as possible.
• Practice session
Participants of the Day group perform a block of motor imagery practice of the two motor tasks.
• MEG recordings (Post-test)
Participants perform the two motor tasks in the MEG (post-test, strictly similar to the pre-test)
• MRI
The registration of the brain anatomy of each participant will be done by MRI 3D / T the week before the first experimental session.

Locations

Country	Name	City	State
France	CH le Vinatier	Bron

Sponsors (1)

Lead Sponsor	Collaborator
Hospices Civils de Lyon

Country where clinical trial is conducted

France, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Evidence of MEG correlates of sleep motor consolidation (day 1)	The investigator will use Single Aperture Magnetometry, i.e. a minimum variance beamformer mapping the spatial distribution of event-related desynchronizations and synchronizations within a predetermined frequency domain (Beta oscillations 15-35 Hz). The time course of MEG Beta power will be considered, and Granger causal connectivity analyses will be performed to investigate relationships between cortical motor regions.	Day 1 at 19h00 [post-training] (Groups 1, 2 and 3) OR Day 1 at 9h00 [post-training] (Group 4)
Primary	Evidence of MEG correlates of sleep motor consolidation (day 2)	The investigator will use Single Aperture Magnetometry, i.e. a minimum variance beamformer mapping the spatial distribution of event-related desynchronizations and synchronizations within a predetermined frequency domain (Beta oscillations 15-35 Hz). The time course of MEG Beta power will be considered, and Granger causal connectivity analyses will be performed to investigate relationships between cortical motor regions.	Day 2 at 9h00 [Retention test] (Groups 1, 2 and 3) OR Day 1 at 19h00 [Retention test] (Group 4)
Secondary	Time needed to complete the motor tasks (day 1)	The investigators will measure the time needed to complete the motor tasks needed to complete each motor task (finger sequential tasks OR motor adaptation task).	Day 1 at 19h00 [post-training] (Groups 1, 2 and 3) OR Day 1 at 9h00 [post-training] (Group 4)
Secondary	Evidence of MEG correlates of sleep motor consolidation	The investigators will use Single Aperture Magnetometry, i.e. a minimum variance beamformer mapping the spatial distribution of event-related desynchronizations and synchronizations within a predetermined frequency domain (Beta oscillations 15-35 Hz). The time course of MEG Beta power will be considered, and Granger causal connectivity analyses will be performed to investigate relationships between cortical motor regions.	Day 2 at 9h00 [Retention test] (Groups 1, 2 and 3) OR Day 1 at 19h00 [Retention test] (Group 4)
Secondary	Accuracy of the motor tasks	The investigators will measure the number of errors and correct trials for each motor task (finger sequential tasks OR motor adaptation task).	Day 1 at 19h00 [post-training] (Groups 1, 2 and 3) OR Day 1 at 9h00 [post-training] (Group 4)
Secondary	Time needed to complete the motor tasks	The investigators will measure the time needed to complete each motor task (finger sequential tasks OR motor adaptation task).	Day 2 at 9h00 [Retention test] (Groups 1, 2 and 3) OR Day 1 at 19h00 [Retention test] (Group 4)
Secondary	Accuracy of the motor tasks 2	The investigators will measure the number of errors and correct trials for each motor task (finger sequential tasks OR motor adaptation task).	Day 2 at 9h00 [Retention test] (Groups 1, 2 and 3) OR Day 1 at 19h00 [Retention test] (Group 4)