Brain and Mindfulness

Healthy Clinical Trial

— MEDITATION  

Official title:

The Impact of Meditation Practice on Attention and Emotion Regulation :Studies on Neural Correlation in Brain Imagery and Biomarkers of Stress and Inflammation

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT03117478
• Other study ID #: 69HCL16_0678
• Status: Completed
• Phase: N/A
• Start date: March 19, 2016
• Est. completion date: October 16, 2019

Study information

• Verified date: June 2021
• Source: Hospices Civils de Lyon
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

The main aim of this project is to explore the neuro-anatomical and -physiological correlates of meditation on attention and emotion-regulation. By investigating this, our scientific goal is to more generally identify the mechanisms and biomarkers of health and mental well-being. Therefore, the investigators use non-invasive imaging like Magneto-EncephaloGraphy (MEG), ElectroEncephaloGraphy (EEG), functional and anatomic Magnetic Resonance Imaging (MRI; including Diffusion tensor - DTI). These brain measures will then be linked to behavioral measurements. Experimental methods (i.e., simple computer tasks) will be used to measure attention, conscious perception and regulation of pain and emotion.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 169
• Est. completion date: October 16, 2019
• Est. primary completion date: October 16, 2019
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 25 Years to 70 Years

Eligibility

Inclusion Criteria:

• Age : 25-70

• Being affiliated to a social security system.

• Motivated to participate in this study.

Exclusion Criteria:

• Medication acting on the central nervous system

• Opioids, Antidepressive Agents.

• Actual or previous neurological or psychiatric illnesses

• Chronic pain or any other medical condition which is related to pain or an increased sensitivity to pain.

• Not having a personal or family history of epilepsy

• Alcohol or drugs consumption 2 days before or during the study.

Related Conditions & MeSH terms

• Healthy

Intervention

Other:
• Magneto-encephalography (MEG)
Magneto-encephalography
• Electro-encephalography (EEG)
Electro-encephalography
• Functional Magnetic Resonance Imaging (fMRI)
Functional Magnetic Resonance Imaging
• Anatomical Magnetic Resonance Imaging (aMRI)
Anatomical Magnetic Resonance Imaging
• Meditation
Meditation

Locations

Country	Name	City	State
France	Le Vinatier	Bron

Sponsors (1)

Lead Sponsor	Collaborator
Hospices Civils de Lyon

Country where clinical trial is conducted

France, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Anatomical MRI scan	Brain structure	Day 1
Primary	Functional MRI scan	Brain activation: Haemodynamic response - BOLD signal.	Day1
Primary	EEG	Event-related potential fields : amplitude in fT and latency in ms. Oscillations : power spectral density and time-frequency oscillations in fT^2/Hz	Day 1
Secondary	Behavioral measure : Accuracy of the performed task actions	Participants will perform behavioral computer tasks in which accuracy and speed is important. Performance behavior will be measured in this task: Accuracy of the performed task actions: number of errors and hits	Day 1
Secondary	Psychophysics: Pain threshold	Pain threshold: The threshold of pain or pain threshold is the point along a curve of increasing perception of a stimulus at which pain begins to be felt. The temperature in degrees Celcius at which heat becomes painful for a recipient.	Day 1
Secondary	Psychophysiology : Respiration	Respiration rate: breaths/minute	Day 1
Secondary	Subjective experience of the participant		Day 1
Secondary	Studies biomarkers of inflammation	area of the inflamed site in mm^2, obtained by automatic image processing of a photography	Day 1
Secondary	Behavioral measure : Speed of the performed task actions	Participants will perform behavioral computer tasks in which accuracy and speed is important. Performance behavior will be measured in this task: Speed of the performed task actions: in ms.	Day 1
Secondary	Psychophysiology : Heart	Heart Rate: pulses/minute	Day 1
Secondary	Psychophysiology : Heart rate variability	Heart rate variability (HRV): Using an electrocardiogram, the variation in the beat-to-beat interval; measured in ms.	Day 1
Secondary	Psychophysiology : Muscles	Electromyography (EMG): Recording the electrical activity produced by muscles; measured in mV.	Day 1
Secondary	Psychophysiology : Eyes	Eye gaze position: relative to center of the screen, in imm	Day 1
Secondary	Psychophysiology : Pupillar response	Pupillar response: pupil diameter, in mm.	Day 1
Secondary	Electrogastrogram	Recording the electrical signals that travel through the stomach muscles and control the muscles' contractions (waves/minute)	Day 1