Connectome Characterization With Aging

Healthy Clinical Trial

— AGE-CONNECT  

Official title:

Connectome Characterization With Aging Using Functional and Structural MRI

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT03109275
• Other study ID #: 69HCL16_0687
• Status: Completed
• Phase: N/A
• Start date: January 22, 2016
• Est. completion date: February 14, 2020

Study information

• Verified date: April 2022
• Source: Hospices Civils de Lyon
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

The main aim of this project is to develop a new model to characterize brain connectivity and its changes with aging. This characterization will be based on new sensitive and specific markers, allowing a better understanding of structural and functional brain networks. To this end, two complementary MRI methods will be developed: 1) Resting-state functional MRI (rs-fMRI) which allows the measurement of cerebral activity in different cortical gray matter regions, and 2) high angular resolution diffusion imaging (HARDI) MRI, which allows to characterize brain tissue microarchitecture. HARDI sequences will be developed to acquire and reconstruct fiber tractography of patient's brains. In combination with conventional MRI, both HARDI and rs-fMRI will be used to estimate the connection degree between each pair of cortical regions, so- called "Connectome". Once generated, brain networks will be quantified through numerous graph metrics, such as graph density, global efficiency and assortativity (etc.), reflecting the organization and topology of subjects' connectivity with aging.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 10
• Est. completion date: February 14, 2020
• Est. primary completion date: February 14, 2020
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 18 Years to 50 Years

Eligibility

Inclusion Criteria:

• Volunteers (Men and women) aged between 18 and 50 years

• No neurological or psychiatric diseases

Exclusion Criteria:

• MRI contraindications

• Pregnant women or nursing women

• Persons under guardianship or any other administrative or deprivation of liberty or of right

Related Conditions & MeSH terms

• Healthy

Intervention

Other:
• Single complete MRI intervention
MRI examination will comprise conventional T1 and FLAIR sequences, and advanced sequences such as rs-fMRI and High angular resolution MRI (HARDI).

Locations

Country	Name	City	State
France	CH le Vinatier	Bron

Sponsors (1)

Lead Sponsor	Collaborator
Hospices Civils de Lyon

Country where clinical trial is conducted

France, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Functional and structural connectivity MRI marker : resting-state fMRI	Functional connectivity of grey matter (GM) using resting-state fMRI	End of study (one year)
Primary	Functional and structural connectivity MRI marker : Functional connectivity	Graph-theory methods analysis of functional connectivity of grey matter	End of study (one year)
Primary	Functional and structural connectivity MRI marker : Diffusion tensor	Structural connectivity of white matter (WM) fiber bundles measured by diffusion tensor imaging	End of study (one year)
Primary	Functional and structural connectivity MRI marker : Structural connectivity	Graph-theory methods analysis of Structural connectivity of white matter (WM) fiber	End of study (one year)
Primary	Functional and structural connectivity MRI marker : SPM software	Cortical and subcortical grey matter (GM) volumes using the SPM software	End of study (one year)
Secondary	Metrics of functional connectivity	Calculation of functional connectivity metrics using graphs theory methods	End of study (one year)