Auditory Deficits in Congenital Amusia (AMUSIE CONGENITALE)

Healthy Clinical Trial

Official title:

Auditory Perceptual and Memory Deficits in Congenital Amusia: Studies of Cerebral Correlates With MEG, Anatomical MRI and Functional MRI

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT03094624
• Other study ID #: 69HCL16_0662
• Status: Completed
• Phase: N/A
• Start date: January 13, 2013
• Est. completion date: May 23, 2019

Study information

• Verified date: June 2021
• Source: Hospices Civils de Lyon
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

The project studies auditory deficits in congenital amusia at the behavioral and neurophysiological levels.

The auditory processes investigated are pitch discrimination, short-term memory, sound-induced emotions. To characterize auditory deficits in the amusic population, neuropsychological assessments are combined with neurophysiological markers (Electro-encephalography: EEG, Magneto-encephalography: MEG, Magnetic Resonance Imaging: MRI).

Recruitment information / eligibility

• Status: Completed
• Enrollment: 230
• Est. completion date: May 23, 2019
• Est. primary completion date: May 23, 2019
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 18 Years to 70 Years

Eligibility

Inclusion Criteria:

• Aged from 18 to 70 years' old

• French

• Compatibility IRM / MEG (no metal in the body)

• Motivation to participate effectively in the project

• No neurological or psychiatric history

• No severe hearing loss

• Informed consent to participate in the study

• For Amusic participants: participant diagnosed amusic by the MBEA (Montreal Battery of Evaluation of Amusia)

• For Control participants: matched in age, sex, education, music education, laterality, non-amusic (controlled with the MBEA)

Exclusion Criteria:

• Age below 18 or above 70

• Non-Francophone volunteers.

• MRI scanning not possible: artificial cardiac pacemaker, insulin pump, metallic prosthesis, intra-cerebral clip, claustrophobia

• MEG acquisition not possible: large heads, neurostimulator, metal in the head or the body.

• Pregnant or breast-feeding women

Related Conditions & MeSH terms

• Amusia, Congenital
• Healthy

Intervention

Other:
• Neuropsychological and neurophysiological tests
Neuropsychological tests consist in listening to sounds in various contexts and providing behavioral responses with response-buttons. Neurophysiological tests consist in the recording of EEG and/or MEG signals or MRI images while realizing the neuropsychological tests, as well as anatomical MRI scanning to characterize the participants' brain anatomy and reconstruct the brain sources of surface EEG/MEG signals.
• Experiment 1
Experiment 1 are interested in perception and musical memory vs. Language and contribute to our understanding of the functional and structural organization of the brain to perceive and memorize music and language.
• Experiment 2
Experiment 2 focuses on perception and musical memory vs. Language and contribute to our understanding of the functional and structural organization of the brain to perceive and memorize music and language. The second experiment will also study short-term memory networks for musical and verbal materials, but the specificity will be the inclusion of a verbal material sung, thus representing the combination of both information. Experiment 2 is divided into two sub-parts. Indeed, the investigators will develop the musical and verbal materials during a first experimental part in experiment (experiment 2a) and then apply them in experimentation MEG (experiment 2b). Experiment 2a will allow us to test new equipment in a short term memory task under conditions that are less restrictive for the participants. Then the investigators will apply the optimal material that emerges for the MEG experiment.
• Experiment 3
Experiment 3 will use Discordant Negativity (MMN; Mismatch Negativity) protocols in coupled EEG-MEG (experiment 3a) and EEG alone (experiment 3b) to investigate memory traces of sensory information. The MMN is used to probe auditory sensory memory (pre-requisite for short- or long-term storage), and has the advantage of being measured without requiring an active task from the participant.
• Experiment 4
Experiment 4 will study the neural correlates of long-term memory for musical and verbal material with fMRI. The testimonies of the amusicians suggest a deficit of the "musical lexicon" which contrasts with that the musical lexicon elaborated of the non-musician listeners.

Locations

Country	Name	City	State
France	Hospices Civils de Lyon, Hôpital Edouard Herriot	Lyon

Sponsors (1)

Lead Sponsor	Collaborator
Hospices Civils de Lyon

Country where clinical trial is conducted

France, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Correct answers to the neuropsychological tests	Percentages of correct responses	Day 1
Primary	Neuropsychological tests reaction times	Neuropsychological tests reaction times	Day 1
Primary	Neurophysiological tests EEG	Event-Related Potentials (EEG)	Day 1
Primary	Neurophysiological tests MEG	Event-Related Fields (MEG)	Day 1
Primary	Neurophysiological tests MRI	MRI images	Day 1